2v26

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[[Image:2v26.jpg|left|200px]]
[[Image:2v26.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2v26 |SIZE=350|CAPTION= <scene name='initialview01'>2v26</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_2v26", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Vo4+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Edo+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Edo+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Edo+Binding+Site+For+Chain+A'>AC6</scene>, <scene name='pdbsite=AC7:Edo+Binding+Site+For+Chain+A'>AC7</scene>, <scene name='pdbsite=AC8:Edo+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=AC9:Edo+Binding+Site+For+Chain+A'>AC9</scene>, <scene name='pdbsite=BC1:Edo+Binding+Site+For+Chain+A'>BC1</scene>, <scene name='pdbsite=BC2:So4+Binding+Site+For+Chain+A'>BC2</scene> and <scene name='pdbsite=BC3:So4+Binding+Site+For+Chain+A'>BC3</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2v26| PDB=2v26 | SCENE= }}
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|RELATEDENTRY=[[2bkh|2BKH]], [[2bki|2BKI]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v26 OCA], [http://www.ebi.ac.uk/pdbsum/2v26 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v26 RCSB]</span>
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}}
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'''MYOSIN VI (MD) PRE-POWERSTROKE STATE (MG.ADP.VO4)'''
'''MYOSIN VI (MD) PRE-POWERSTROKE STATE (MG.ADP.VO4)'''
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[[Category: Mukherjea, M.]]
[[Category: Mukherjea, M.]]
[[Category: Sweeney, H L.]]
[[Category: Sweeney, H L.]]
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[[Category: actin-binding]]
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[[Category: Actin-binding]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: calmodulin-binding]]
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[[Category: Calmodulin-binding]]
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[[Category: coiled coil]]
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[[Category: Coiled coil]]
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[[Category: domain motor]]
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[[Category: Domain motor]]
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[[Category: endocytosis]]
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[[Category: Endocytosis]]
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[[Category: golgi apparatus]]
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[[Category: Golgi apparatus]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: molecular motor]]
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[[Category: Molecular motor]]
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[[Category: motor protein]]
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[[Category: Motor protein]]
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[[Category: myosin]]
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[[Category: Myosin]]
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[[Category: myosin vi]]
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[[Category: Myosin vi]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: pre- powerstroke]]
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[[Category: Pre- powerstroke]]
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[[Category: protein transport]]
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[[Category: Protein transport]]
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[[Category: structural protein]]
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[[Category: Structural protein]]
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[[Category: transition state]]
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[[Category: Transition state]]
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[[Category: transport]]
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[[Category: Transport]]
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[[Category: vanadate]]
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[[Category: Vanadate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:05:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:07:41 2008''
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Revision as of 15:05, 4 May 2008

Image:2v26.jpg

Template:STRUCTURE 2v26

MYOSIN VI (MD) PRE-POWERSTROKE STATE (MG.ADP.VO4)


Overview

Due to a unique addition to the lever arm-positioning region (converter), class VI myosins move in the opposite direction (toward the minus-end of actin filaments) compared to other characterized myosin classes. However, the large size of the myosin VI lever arm swing (powerstroke) cannot be explained by our current view of the structural transitions that occur within the myosin motor. We have solved the crystal structure of a fragment of the myosin VI motor in the structural state that represents the starting point for movement on actin; the pre-powerstroke state. Unexpectedly, the converter itself rearranges to achieve a conformation that has not been seen for other myosins. This results in a much larger powerstroke than is achievable without the converter rearrangement. Moreover, it provides a new mechanism that could be exploited to increase the powerstroke of yet to be characterized plus-end-directed myosin classes.

About this Structure

2V26 is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.

Reference

The structural basis for the large powerstroke of myosin VI., Menetrey J, Llinas P, Mukherjea M, Sweeney HL, Houdusse A, Cell. 2007 Oct 19;131(2):300-8. PMID:17956731 Page seeded by OCA on Sun May 4 18:05:03 2008

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