2v2t

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[[Image:2v2t.jpg|left|200px]]
[[Image:2v2t.jpg|left|200px]]
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{{Structure
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|PDB= 2v2t |SIZE=350|CAPTION= <scene name='initialview01'>2v2t</scene>, resolution 3.05&Aring;
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The line below this paragraph, containing "STRUCTURE_2v2t", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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{{STRUCTURE_2v2t| PDB=2v2t | SCENE= }}
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|RELATEDENTRY=[[1bfs|1BFS]], [[1ikn|1IKN]], [[1le5|1LE5]], [[1le9|1LE9]], [[1lei|1LEI]], [[1nfk|1NFK]], [[1ooa|1OOA]], [[1u36|1U36]], [[1u3j|1U3J]], [[1u3y|1U3Y]], [[1u3z|1U3Z]], [[1u41|1U41]], [[1u42|1U42]], [[1vkx|1VKX]], [[1zk9|1ZK9]], [[1zka|1ZKA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2t OCA], [http://www.ebi.ac.uk/pdbsum/2v2t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v2t RCSB]</span>
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'''X-RAY STRUCTURE OF A NF-KB P50-RELB-DNA COMPLEX'''
'''X-RAY STRUCTURE OF A NF-KB P50-RELB-DNA COMPLEX'''
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[[Category: Wang, V Y.]]
[[Category: Wang, V Y.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:06:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:07:58 2008''
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Revision as of 15:06, 4 May 2008

Template:STRUCTURE 2v2t

X-RAY STRUCTURE OF A NF-KB P50-RELB-DNA COMPLEX


Overview

We describe here the X-ray crystal structure of NF-kappaB p50/RelB heterodimer bound to a kappaB DNA. Although the global modes of subunit association and kappaB DNA recognition are similar to other NF-kappaB/DNA complexes, this complex reveals distinctive features not observed for non-RelB complexes. For example, Lys274 of RelB is removed from the protein-DNA interface whereas the corresponding residues in all other subunits make base-specific contacts. This mode of binding suggests that RelB may allow the recognition of more diverse kappaB sequences. Complementary surfaces on RelB and p50, as revealed by the crystal contacts, are highly suggestive of assembly of multiple p50/RelB heterodimers on tandem kappaB sites in solution. Consistent with this model our in vitro binding experiments reveal optimal assembly of two wild-type p50/RelB heterodimers on tandem HIV kappaB DNA with 2 bp spacing but not by a mutant heterodimer where one of the RelB packing surface is altered. We suggest that multiple NF-kappaB dimers assemble at diverse kappaB promoters through direct interactions utilizing unique protein-protein interaction surfaces.

About this Structure

2V2T is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites., Moorthy AK, Huang DB, Wang VY, Vu D, Ghosh G, J Mol Biol. 2007 Oct 26;373(3):723-34. Epub 2007 Aug 22. PMID:17869269 Page seeded by OCA on Sun May 4 18:06:52 2008

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