2v3b

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[[Image:2v3b.jpg|left|200px]]
[[Image:2v3b.jpg|left|200px]]
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{{Structure
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|PDB= 2v3b |SIZE=350|CAPTION= <scene name='initialview01'>2v3b</scene>, resolution 2.45&Aring;
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The line below this paragraph, containing "STRUCTURE_2v3b", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Fe+Binding+Site+For+Chain+B'>AC1</scene>
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|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
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{{STRUCTURE_2v3b| PDB=2v3b | SCENE= }}
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|RELATEDENTRY=[[2v3a|2V3A]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v3b OCA], [http://www.ebi.ac.uk/pdbsum/2v3b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v3b RCSB]</span>
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'''CRYSTAL STRUCTURE OF THE ELECTRON TRANSFER COMPLEX RUBREDOXIN- RUBREDOXIN REDUCTASE FROM PSEUDOMONAS AERUGINOSA.'''
'''CRYSTAL STRUCTURE OF THE ELECTRON TRANSFER COMPLEX RUBREDOXIN- RUBREDOXIN REDUCTASE FROM PSEUDOMONAS AERUGINOSA.'''
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[[Category: Tuemmler, B.]]
[[Category: Tuemmler, B.]]
[[Category: Wiehlmann, L.]]
[[Category: Wiehlmann, L.]]
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[[Category: alkane degradation]]
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[[Category: Alkane degradation]]
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[[Category: electron transfer]]
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[[Category: Electron transfer]]
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[[Category: electron transport]]
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[[Category: Electron transport]]
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[[Category: fad]]
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[[Category: Fad]]
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[[Category: flavoprotein]]
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[[Category: Flavoprotein]]
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[[Category: Iron]]
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[[Category: iron-sulfur protein]]
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[[Category: Iron-sulfur protein]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: nad]]
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[[Category: Nad]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:08:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:08:02 2008''
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Revision as of 15:08, 4 May 2008

Image:2v3b.jpg

Template:STRUCTURE 2v3b

CRYSTAL STRUCTURE OF THE ELECTRON TRANSFER COMPLEX RUBREDOXIN- RUBREDOXIN REDUCTASE FROM PSEUDOMONAS AERUGINOSA.


Overview

Crude oil spills represent a major ecological threat because of the chemical inertness of the constituent n-alkanes. The Gram-negative bacterium Pseudomonas aeruginosa is one of the few bacterial species able to metabolize such compounds. Three chromosomal genes, rubB, rubA1, and rubA2 coding for an NAD(P)H:rubredoxin reductase (RdxR) and two rubredoxins (Rdxs) are indispensable for this ability. They constitute an electron transport (ET) pathway that shuttles reducing equivalents from carbon metabolism to the membrane-bound alkane hydroxylases AlkB1 and AlkB2. The RdxR-Rdx system also is crucial as part of the oxidative stress response in archaea or anaerobic bacteria. The redox couple has been analyzed in detail as a model system for ET processes. We have solved the structure of RdxR of P. aeruginosa both alone and in complex with Rdx, without the need for cross-linking, and both structures were refined at 2.40- and 2.45-A resolution, respectively. RdxR consists of two cofactor-binding domains and a C-terminal domain essential for the specific recognition of Rdx. Only a small number of direct interactions govern mutual recognition of RdxR and Rdx, corroborating the transient nature of the complex. The shortest distance between the redox centers is observed to be 6.2 A.

About this Structure

2V3B is a Protein complex structure of sequences from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Crystal structure of the electron transfer complex rubredoxin rubredoxin reductase of Pseudomonas aeruginosa., Hagelueken G, Wiehlmann L, Adams TM, Kolmar H, Heinz DW, Tummler B, Schubert WD, Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12276-81. Epub 2007 Jul 16. PMID:17636129 Page seeded by OCA on Sun May 4 18:08:19 2008

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