2v5y

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[[Image:2v5y.jpg|left|200px]]
[[Image:2v5y.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2v5y |SIZE=350|CAPTION= <scene name='initialview01'>2v5y</scene>, resolution 3.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2v5y", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2v5y| PDB=2v5y | SCENE= }}
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|RELATEDENTRY=[[1rpm|1RPM]], [[2c9a|2C9A]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5y OCA], [http://www.ebi.ac.uk/pdbsum/2v5y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v5y RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU ECTODOMAIN'''
'''CRYSTAL STRUCTURE OF THE RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU ECTODOMAIN'''
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[[Category: Merwe, P A.Van Der.]]
[[Category: Merwe, P A.Van Der.]]
[[Category: Siebold, C.]]
[[Category: Siebold, C.]]
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[[Category: cell adhesion]]
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[[Category: Cell adhesion]]
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[[Category: extracellular region]]
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[[Category: Extracellular region]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: immunoglobulin domain]]
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[[Category: Immunoglobulin domain]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: protein phosphatase]]
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[[Category: Protein phosphatase]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: receptor protein tyrosine phosphatase]]
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[[Category: Receptor protein tyrosine phosphatase]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:14:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:08:36 2008''
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Revision as of 15:14, 4 May 2008

Image:2v5y.jpg

Template:STRUCTURE 2v5y

CRYSTAL STRUCTURE OF THE RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU ECTODOMAIN


Overview

Cell-cell contacts are fundamental to multicellular organisms and are subject to exquisite levels of control. Human RPTPmu is a type IIB receptor protein tyrosine phosphatase that both forms an adhesive contact itself and is involved in regulating adhesion by dephosphorylating components of cadherin-catenin complexes. Here we describe a 3.1 angstrom crystal structure of the RPTPmu ectodomain that forms a homophilic trans (antiparallel) dimer with an extended and rigid architecture, matching the dimensions of adherens junctions. Cell surface expression of deletion constructs induces intercellular spacings that correlate with the ectodomain length. These data suggest that the RPTPmu ectodomain acts as a distance gauge and plays a key regulatory function, locking the phosphatase to its appropriate functional location.

About this Structure

2V5Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism., Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ, van der Merwe PA, Jones EY, Science. 2007 Aug 31;317(5842):1217-20. PMID:17761881 Page seeded by OCA on Sun May 4 18:14:21 2008

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OCA

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