2v8j

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[[Image:2v8j.jpg|left|200px]]
[[Image:2v8j.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2v8j |SIZE=350|CAPTION= <scene name='initialview01'>2v8j</scene>, resolution 2.01&Aring;
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The line below this paragraph, containing "STRUCTURE_2v8j", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mn+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pectate_lyase Pectate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.2 4.2.2.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2v8j| PDB=2v8j | SCENE= }}
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|RELATEDENTRY=[[2v8i|2V8I]], [[2v8k|2V8K]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v8j OCA], [http://www.ebi.ac.uk/pdbsum/2v8j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v8j RCSB]</span>
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}}
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'''STRUCTURE OF A FAMILY 2 PECTATE LYASE IN COMPLEX WITH A TRANSITION METAL'''
'''STRUCTURE OF A FAMILY 2 PECTATE LYASE IN COMPLEX WITH A TRANSITION METAL'''
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[[Category: Abbott, D W.]]
[[Category: Abbott, D W.]]
[[Category: Boraston, A B.]]
[[Category: Boraston, A B.]]
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[[Category: beta-elimination]]
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[[Category: Beta-elimination]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: pectate lyase]]
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[[Category: Pectate lyase]]
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[[Category: pectin degradation]]
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[[Category: Pectin degradation]]
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[[Category: periplasm]]
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[[Category: Periplasm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:22:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:09:35 2008''
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Revision as of 15:22, 4 May 2008

Image:2v8j.jpg

Template:STRUCTURE 2v8j

STRUCTURE OF A FAMILY 2 PECTATE LYASE IN COMPLEX WITH A TRANSITION METAL


Overview

The family 2 pectate lyase from Yersinia enterocolitica (YePL2A), solved to 1.5A, reveals it to be the first prokaryotic protein reported to display the rare (alpha/alpha)(7) barrel fold. In addition to its apo form, we have also determined the structure of a metal-bound form of YePL2A (to 2.0A) and a trigalacturonic acid-bound substrate complex (to 2.1A) Although its fold is rare, the catalytic center of YePL2A can be superimposed with structurally unrelated families, underlining the conserved catalytic amino acid architecture of the beta-elimination mechanism. In addition to its overall structure, YePL2A also has two other unique features: 1) it utilizes a metal atom other than calcium for catalysis, and 2) its Bronstead base is in an alternate conformation and directly interacts with the uronate group of the substrate.

About this Structure

2V8J is a Single protein structure of sequence from Yersinia enterocolitica. Full crystallographic information is available from OCA.

Reference

A family 2 pectate lyase displays a rare fold and transition metal-assisted beta-elimination., Abbott DW, Boraston AB, J Biol Chem. 2007 Nov 30;282(48):35328-36. Epub 2007 Sep 19. PMID:17881361 Page seeded by OCA on Sun May 4 18:22:22 2008

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