2v8o

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[[Image:2v8o.gif|left|200px]]
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{{Structure
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|PDB= 2v8o |SIZE=350|CAPTION= <scene name='initialview01'>2v8o</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2v8o", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91] </span>
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{{STRUCTURE_2v8o| PDB=2v8o | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v8o OCA], [http://www.ebi.ac.uk/pdbsum/2v8o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v8o RCSB]</span>
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'''STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS RNA HELICASE TO 1.9A RESOLUTION'''
'''STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS RNA HELICASE TO 1.9A RESOLUTION'''
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[[Category: Verma, A.]]
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[[Category: Murray valley encephalitis virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:22:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:09:35 2008''
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Revision as of 15:22, 4 May 2008

Image:2v8o.gif

Template:STRUCTURE 2v8o

STRUCTURE OF THE MURRAY VALLEY ENCEPHALITIS VIRUS RNA HELICASE TO 1.9A RESOLUTION


Overview

Murray Valley encephalitis virus (MVEV), a mosquito-borne flavivirus endemic to Australia, is closely related to Japanese encephalitis virus and West Nile virus. Nonstructural protein 3 (NS3) is a multifunctional enzyme with serine protease and DEXH/D-box helicase domains, whose activity is central to flavivirus replication and is therefore a possible target for anti-flaviviral compounds. Cloning, purification, and crystal structure determination to 1.9 Angstrom resolution of the NS3 helicase of MVEV and characterization of its enzymatic activity is reported. Comparison with the structures of helicases from related viruses supports a possible mechanism of ATP hydrolysis-driven strand separation.

About this Structure

2V8O is a Single protein structure of sequence from Murray valley encephalitis virus. Full crystallographic information is available from OCA.

Reference

Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution., Mancini EJ, Assenberg R, Verma A, Walter TS, Tuma R, Grimes JM, Owens RJ, Stuart DI, Protein Sci. 2007 Oct;16(10):2294-300. PMID:17893366 Page seeded by OCA on Sun May 4 18:22:40 2008

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OCA

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