2v9a

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[[Image:2v9a.jpg|left|200px]]
[[Image:2v9a.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2v9a |SIZE=350|CAPTION= <scene name='initialview01'>2v9a</scene>, resolution 2.&Aring;
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The line below this paragraph, containing "STRUCTURE_2v9a", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG3290 CitA]</span>
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{{STRUCTURE_2v9a| PDB=2v9a | SCENE= }}
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|RELATEDENTRY=[[1p0z|1P0Z]], [[2j80|2J80]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9a OCA], [http://www.ebi.ac.uk/pdbsum/2v9a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v9a RCSB]</span>
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'''STRUCTURE OF CITRATE-FREE PERIPLASMIC DOMAIN OF SENSOR HISTIDINE KINASE CITA'''
'''STRUCTURE OF CITRATE-FREE PERIPLASMIC DOMAIN OF SENSOR HISTIDINE KINASE CITA'''
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[[Category: Vijayan, V.]]
[[Category: Vijayan, V.]]
[[Category: Zweckstetter, M.]]
[[Category: Zweckstetter, M.]]
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[[Category: cita]]
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[[Category: Cita]]
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[[Category: inner membrane]]
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[[Category: Inner membrane]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: sensor domain]]
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[[Category: Sensor domain]]
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[[Category: sensor histidine kinase]]
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[[Category: Sensor histidine kinase]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: two-component regulatory system]]
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[[Category: Two-component regulatory system]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:24:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:09:52 2008''
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Revision as of 15:24, 4 May 2008

Image:2v9a.jpg

Template:STRUCTURE 2v9a

STRUCTURE OF CITRATE-FREE PERIPLASMIC DOMAIN OF SENSOR HISTIDINE KINASE CITA


Overview

Sensor histidine kinases of two-component signal-transduction systems are essential for bacteria to adapt to variable environmental conditions. However, despite their prevalence, it is not well understood how extracellular signals such as ligand binding regulate the activity of these sensor kinases. CitA is the sensor histidine kinase in Klebsiella pneumoniae that regulates the transport and anaerobic metabolism of citrate in response to its extracellular concentration. We report here the X-ray structures of the periplasmic sensor domain of CitA in the citrate-free and citrate-bound states. A comparison of the two structures shows that ligand binding causes a considerable contraction of the sensor domain. This contraction may represent the molecular switch that activates transmembrane signaling in the receptor.

About this Structure

2V9A is a Single protein structure of sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA.

Reference

A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA., Sevvana M, Vijayan V, Zweckstetter M, Reinelt S, Madden DR, Herbst-Irmer R, Sheldrick GM, Bott M, Griesinger C, Becker S, J Mol Biol. 2008 Mar 21;377(2):512-23. Epub 2008 Jan 16. PMID:18258261 Page seeded by OCA on Sun May 4 18:24:52 2008

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