2v9y

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[[Image:2v9y.jpg|left|200px]]
[[Image:2v9y.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2v9y |SIZE=350|CAPTION= <scene name='initialview01'>2v9y</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2v9y", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+B'>AC2</scene> and <scene name='pdbsite=AC3:So4+Binding+Site+For+Chain+B'>AC3</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_cyclo-ligase Phosphoribosylformylglycinamidine cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.1 6.3.3.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2v9y| PDB=2v9y | SCENE= }}
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|RELATEDENTRY=[[1mej|1MEJ]], [[1men|1MEN]], [[1meo|1MEO]], [[1zly|1ZLY]], [[1njs|1NJS]], [[1zlx|1ZLX]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9y OCA], [http://www.ebi.ac.uk/pdbsum/2v9y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2v9y RCSB]</span>
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}}
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'''HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE'''
'''HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE'''
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[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
[[Category: Welin, M.]]
[[Category: Welin, M.]]
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[[Category: air]]
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[[Category: Air]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: aminoimidazole ribonucleotide synthetase]]
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[[Category: Aminoimidazole ribonucleotide synthetase]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: gart]]
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[[Category: Gart]]
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[[Category: ligase]]
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[[Category: Ligase]]
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[[Category: multifunctional enzyme]]
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[[Category: Multifunctional enzyme]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: purine biosynthesis]]
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[[Category: Purine biosynthesis]]
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[[Category: purine metabolism]]
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[[Category: Purine metabolism]]
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[[Category: sgc]]
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[[Category: Sgc]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural genomics consortium]]
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[[Category: Structural genomics consortium]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:27:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:10:11 2008''
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Revision as of 15:28, 4 May 2008

Image:2v9y.jpg

Template:STRUCTURE 2v9y

HUMAN AMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE


Overview

We tested the general applicability of in situ proteolysis to form protein crystals suitable for structure determination by adding a protease (chymotrypsin or trypsin) digestion step to crystallization trials of 55 bacterial and 14 human proteins that had proven recalcitrant to our best efforts at crystallization or structure determination. This is a work in progress; so far we determined structures of 9 bacterial proteins and the human aminoimidazole ribonucleotide synthetase (AIRS) domain.

About this Structure

2V9Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

In situ proteolysis for protein crystallization and structure determination., Dong A, Xu X, Edwards AM, Chang C, Chruszcz M, Cuff M, Cymborowski M, Di Leo R, Egorova O, Evdokimova E, Filippova E, Gu J, Guthrie J, Ignatchenko A, Joachimiak A, Klostermann N, Kim Y, Korniyenko Y, Minor W, Que Q, Savchenko A, Skarina T, Tan K, Yakunin A, Yee A, Yim V, Zhang R, Zheng H, Akutsu M, Arrowsmith C, Avvakumov GV, Bochkarev A, Dahlgren LG, Dhe-Paganon S, Dimov S, Dombrovski L, Finerty P Jr, Flodin S, Flores A, Graslund S, Hammerstrom M, Herman MD, Hong BS, Hui R, Johansson I, Liu Y, Nilsson M, Nedyalkova L, Nordlund P, Nyman T, Min J, Ouyang H, Park HW, Qi C, Rabeh W, Shen L, Shen Y, Sukumard D, Tempel W, Tong Y, Tresagues L, Vedadi M, Walker JR, Weigelt J, Welin M, Wu H, Xiao T, Zeng H, Zhu H, Nat Methods. 2007 Dec;4(12):1019-21. Epub 2007 Nov 4. PMID:17982461 Page seeded by OCA on Sun May 4 18:27:57 2008

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OCA

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