2vb6

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[[Image:2vb6.jpg|left|200px]]
[[Image:2vb6.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2vb6 |SIZE=350|CAPTION= <scene name='initialview01'>2vb6</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2vb6", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Bef+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Ca+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=AC5:Ca+Binding+Site+For+Chain+B'>AC5</scene>, <scene name='pdbsite=AC6:Ca+Binding+Site+For+Chain+B'>AC6</scene> and <scene name='pdbsite=AC7:Ca+Binding+Site+For+Chain+B'>AC7</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2vb6| PDB=2vb6 | SCENE= }}
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|RELATEDENTRY=[[2bkh|2BKH]], [[2v26|2V26]], [[2bki|2BKI]], [[2vas|2VAS]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vb6 OCA], [http://www.ebi.ac.uk/pdbsum/2vb6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vb6 RCSB]</span>
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}}
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'''MYOSIN VI (MD-INSERT2-CAM, DELTA INSERT1) POST-RIGOR STATE (CRYSTAL FORM 2)'''
'''MYOSIN VI (MD-INSERT2-CAM, DELTA INSERT1) POST-RIGOR STATE (CRYSTAL FORM 2)'''
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[[Category: Squires, G.]]
[[Category: Squires, G.]]
[[Category: Sweeney, H L.]]
[[Category: Sweeney, H L.]]
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[[Category: calmodulin]]
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[[Category: Calmodulin]]
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[[Category: cam]]
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[[Category: Cam]]
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[[Category: mg adp befx]]
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[[Category: Mg adp befx]]
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[[Category: molecular motor]]
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[[Category: Molecular motor]]
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[[Category: motor protein]]
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[[Category: Motor protein]]
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[[Category: myosin vi]]
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[[Category: Myosin vi]]
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[[Category: post-rigor state]]
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[[Category: Post-rigor state]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:32:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:10:33 2008''
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Revision as of 15:32, 4 May 2008

Image:2vb6.jpg

Template:STRUCTURE 2vb6

MYOSIN VI (MD-INSERT2-CAM, DELTA INSERT1) POST-RIGOR STATE (CRYSTAL FORM 2)


Overview

Myosin VI has an unexpectedly large swing of its lever arm (powerstroke) that optimizes its unique reverse direction movement. The basis for this is an unprecedented rearrangement of the subdomain to which the lever arm is attached, referred to as the converter. It is unclear at what point(s) in the myosin VI ATPase cycle rearrangements in the converter occur, and how this would effect lever arm position. We solved the structure of myosin VI with an ATP analogue (ADP.BeF3) bound in its nucleotide-binding pocket. The structure reveals that no rearrangement in the converter occur upon ATP binding. Based on previously solved myosin structures, our structure suggests that no reversal of the powerstroke occurs during detachment of myosin VI from actin. The structure also reveals novel features of the myosin VI motor that may be important in maintaining the converter conformation during detachment from actin, and other features that may promote rapid rearrangements in the structure following actin detachment that enable hydrolysis of ATP.

About this Structure

2VB6 is a Protein complex structure of sequences from Gallus gallus and Sus scrofa. Full crystallographic information is available from OCA.

Reference

The post-rigor structure of myosin VI and implications for the recovery stroke., Menetrey J, Llinas P, Cicolari J, Squires G, Liu X, Li A, Sweeney HL, Houdusse A, EMBO J. 2008 Jan 9;27(1):244-52. Epub 2007 Nov 29. PMID:18046460 Page seeded by OCA on Sun May 4 18:32:09 2008

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