2vee

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2vee.jpg|left|200px]]
[[Image:2vee.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2vee |SIZE=350|CAPTION= <scene name='initialview01'>2vee</scene>, resolution 2.60&Aring;
+
The line below this paragraph, containing "STRUCTURE_2vee", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Hem+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Hem+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:Hem+Binding+Site+For+Chain+C'>AC3</scene>, <scene name='pdbsite=AC4:Hem+Binding+Site+For+Chain+D'>AC4</scene>, <scene name='pdbsite=AC5:Hem+Binding+Site+For+Chain+E'>AC5</scene>, <scene name='pdbsite=AC6:Hem+Binding+Site+For+Chain+F'>AC6</scene>, <scene name='pdbsite=AC7:Hem+Binding+Site+For+Chain+G'>AC7</scene> and <scene name='pdbsite=AC8:Hem+Binding+Site+For+Chain+H'>AC8</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2vee| PDB=2vee | SCENE= }}
-
|RELATEDENTRY=[[2veb|2VEB]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vee OCA], [http://www.ebi.ac.uk/pdbsum/2vee PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vee RCSB]</span>
+
-
}}
+
'''STRUCTURE OF PROTOGLOBIN FROM METHANOSARCINA ACETIVORANS C2A'''
'''STRUCTURE OF PROTOGLOBIN FROM METHANOSARCINA ACETIVORANS C2A'''
Line 36: Line 33:
[[Category: Saito, J A.]]
[[Category: Saito, J A.]]
[[Category: Thijs, L.]]
[[Category: Thijs, L.]]
-
[[Category: archaea protein]]
+
[[Category: Archaea protein]]
-
[[Category: hemoprotein structure]]
+
[[Category: Hemoprotein structure]]
-
[[Category: methanogenesis]]
+
[[Category: Methanogenesis]]
-
[[Category: protein matrix tunnel]]
+
[[Category: Protein matrix tunnel]]
-
[[Category: protoglobin]]
+
[[Category: Protoglobin]]
-
[[Category: transport protein]]
+
[[Category: Transport protein]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:39:28 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:11:13 2008''
+

Revision as of 15:39, 4 May 2008

Image:2vee.jpg

Template:STRUCTURE 2vee

STRUCTURE OF PROTOGLOBIN FROM METHANOSARCINA ACETIVORANS C2A


Overview

The structural adaptability of the globin fold has been highlighted by the recent discovery of the 2-on-2 haemoglobins, of neuroglobin and cytoglobin. Protoglobin from Methanosarcina acetivorans C2A-a strictly anaerobic methanogenic Archaea-is, to the best of our knowledge, the latest entry adding new variability and functional complexity to the haemoglobin (Hb) superfamily. Here, we report the 1.3 A crystal structure of oxygenated M. acetivorans protoglobin, together with the first insight into its ligand-binding properties. We show that, contrary to all known globins, protoglobin-specific loops and an amino-terminal extension completely bury the haem within the protein matrix. Access of O(2), CO and NO to the haem is granted by the protoglobin-specific apolar tunnels reaching the haem distal site from locations at the B/G and B/E helix interfaces. Functionally, M. acetivorans dimeric protoglobin shows a selectivity ratio for O(2)/CO binding to the haem that favours O(2) ligation and anticooperativity in ligand binding. Both properties are exceptional within the Hb superfamily.

About this Structure

2VEE is a Single protein structure of sequence from Methanosarcina acetivorans. Full crystallographic information is available from OCA.

Reference

Archaeal protoglobin structure indicates new ligand diffusion paths and modulation of haem-reactivity., Nardini M, Pesce A, Thijs L, Saito JA, Dewilde S, Alam M, Ascenzi P, Coletta M, Ciaccio C, Moens L, Bolognesi M, EMBO Rep. 2008 Feb;9(2):157-63. Epub 2008 Jan 11. PMID:18188182 Page seeded by OCA on Sun May 4 18:39:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vee"
Personal tools