2vfj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2vfj.jpg|left|200px]]
[[Image:2vfj.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2vfj |SIZE=350|CAPTION= <scene name='initialview01'>2vfj</scene>, resolution 3.2&Aring;
+
The line below this paragraph, containing "STRUCTURE_2vfj", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+C'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+D'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Chain+C'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Chain+D'>AC4</scene> and <scene name='pdbsite=AC5:Mg+Binding+Site+For+Chain+D'>AC5</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2vfj| PDB=2vfj | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vfj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vfj OCA], [http://www.ebi.ac.uk/pdbsum/2vfj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vfj RCSB]</span>
+
-
}}
+
'''STRUCTURE OF THE A20 OVARIAN TUMOUR (OTU) DOMAIN'''
'''STRUCTURE OF THE A20 OVARIAN TUMOUR (OTU) DOMAIN'''
Line 28: Line 25:
[[Category: Barford, D.]]
[[Category: Barford, D.]]
[[Category: Komander, D.]]
[[Category: Komander, D.]]
-
[[Category: apoptosis]]
+
[[Category: Apoptosis]]
-
[[Category: cysteine protease]]
+
[[Category: Cysteine protease]]
-
[[Category: cytokine signalling]]
+
[[Category: Cytokine signalling]]
-
[[Category: cytoplasm]]
+
[[Category: Cytoplasm]]
-
[[Category: deubiquitinating enzyme]]
+
[[Category: Deubiquitinating enzyme]]
-
[[Category: dna-binding]]
+
[[Category: Dna-binding]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: lys63- linked]]
+
[[Category: Lys63- linked]]
-
[[Category: metal-binding]]
+
[[Category: Metal-binding]]
-
[[Category: nf-kb]]
+
[[Category: Nf-kb]]
-
[[Category: nucleus]]
+
[[Category: Nucleus]]
-
[[Category: otu]]
+
[[Category: Otu]]
-
[[Category: ovarian tumour]]
+
[[Category: Ovarian tumour]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: polymorphism]]
+
[[Category: Polymorphism]]
-
[[Category: protease]]
+
[[Category: Protease]]
-
[[Category: thiol protease]]
+
[[Category: Thiol protease]]
-
[[Category: ubiquitin]]
+
[[Category: Ubiquitin]]
-
[[Category: ubl conjugation pathway]]
+
[[Category: Ubl conjugation pathway]]
-
[[Category: zinc]]
+
[[Category: Zinc]]
-
[[Category: zinc-finger]]
+
[[Category: Zinc-finger]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:42:47 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:11:34 2008''
+

Revision as of 15:42, 4 May 2008

Image:2vfj.jpg

Template:STRUCTURE 2vfj

STRUCTURE OF THE A20 OVARIAN TUMOUR (OTU) DOMAIN


Overview

The NF-kappaB (nuclear factor kappaB) regulator A20 antagonises IKK [IkappaB (inhibitor of kappaB) kinase] activation by modulating Lys63-linked polyubiquitination of cytokine-receptor-associated factors including TRAF2/6 (tumour-necrosis-factor-receptor-associated factor 2/6) and RIP1 (receptor-interacting protein 1). In the present paper we describe the crystal structure of the N-terminal OTU (ovarian tumour) deubiquitinase domain of A20, which differs from other deubiquitinases but shares the minimal catalytic core with otubain-2. Analysis of conserved surface regions allows prediction of ubiquitin-binding sites for the proximal and distal ubiquitin molecules. Structural and biochemical analysis suggests a novel architecture of the catalytic triad, which might be present in a subset of OTU domains including Cezanne and TRABID (TRAF-binding domain). Biochemical analysis shows a preference of the isolated A20 OTU domain for Lys48-linked tetraubiquitin in vitro suggesting that additional specificity factors might be required for the physiological function of A20 in cells.

About this Structure

2VFJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the A20 OTU domain and mechanistic insights into deubiquitination., Komander D, Barford D, Biochem J. 2008 Jan 1;409(1):77-85. PMID:17961127 Page seeded by OCA on Sun May 4 18:42:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vfj"
Personal tools