1o8c
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(New page: 200px<br /> <applet load="1o8c" size="450" color="white" frame="true" align="right" spinBox="true" caption="1o8c, resolution 2.60Å" /> '''CRYSTAL STRUCTURE O...)
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Revision as of 17:14, 29 October 2007
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CRYSTAL STRUCTURE OF E. COLI K-12 YHDH WITH BOUND NADPH
Overview
As part of a structural genomics project on bacterial gene products of, unknown function, the crystal structures of YhdH, a putative quinone, oxidoreductase, and its complex with NADP have been determined at 2.25 and, 2.6 A resolution, respectively. The overall fold of YhdH is very similar, to that of alcohol dehydrogenases and quinone reductases despite its low, sequence identity. The absence of any Zn ion indicates that YdhH is a, putative quinone oxidoreductase. YhdH forms a homodimer, with each subunit, composed of two domains: a catalytic domain and a coenzyme-binding domain., NADP is bound in a deep cleft formed between the two domains. Large, conformational changes occur upon NADP binding, with the two domains, closing up to each other and narrowing the NADP-binding cleft. ... [(full description)]
About this Structure
1O8C is a [Single protein] structure of sequence from [Escherichia coli] with NDP as [ligand]. Full crystallographic information is available from [OCA].
Reference
Structure of Escherichia coli YhdH, a putative quinone oxidoreductase., Sulzenbacher G, Roig-Zamboni V, Pagot F, Grisel S, Salomoni A, Valencia C, Campanacci V, Vincentelli R, Tegoni M, Eklund H, Cambillau C, Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1855-62. Epub 2004, Sep 23. PMID:15388933
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