2vl5
From Proteopedia
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'''STRUCTURE OF ANTI-COLLAGEN TYPE II FAB CIIC1''' | '''STRUCTURE OF ANTI-COLLAGEN TYPE II FAB CIIC1''' | ||
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[[Category: Thunnissen, M M.]] | [[Category: Thunnissen, M M.]] | ||
[[Category: Uysal, H.]] | [[Category: Uysal, H.]] | ||
| - | [[Category: | + | [[Category: Arthritis]] |
| - | [[Category: | + | [[Category: Autoantibody]] |
| - | [[Category: | + | [[Category: Collagen type ii]] |
| - | [[Category: | + | [[Category: Immune system]] |
| - | [[Category: | + | [[Category: Rheumatoid factor]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:59:02 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 15:59, 4 May 2008
STRUCTURE OF ANTI-COLLAGEN TYPE II FAB CIIC1
Overview
Monoclonal anti-collagen type II antibody CIIC1 is an arthritogenic autoantibody, which induces arthritis in mice. We crystallized and solved the structure of CIIC1 Fab molecule. Analysis of structure revealed an interaction between the CDR regions of one Fab to the CH1 domain of another Fab, which resembles an antibody-antigen interaction. ELISA experiments confirmed the cross-reactivity of both the full CIIC1 antibody and a single chain Fv fragment to other anti-collagen antibodies which are of different isotypes and epitope specificity. The rheumatoid factor like reactivity of CIIC1 antibody together with its collagen type II specificity may explain the pathogenicity of this antibody.
About this Structure
2VL5 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab: Structure to function analysis., Uysal H, Sehnert B, Nandakumar KS, Boiers U, Burkhardt H, Holmdahl R, Thunnissen MM, Mol Immunol. 2008 Apr;45(8):2196-204. Epub 2008 Feb 1. PMID:18241923 Page seeded by OCA on Sun May 4 18:59:02 2008
