1ab8
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1ab8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ab8, resolution 2.2Å" /> '''RAT TYPE II ADENYLYL ...)
Next diff →
Revision as of 08:36, 20 November 2007
|
RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX
Overview
Mammalian adenylyl cyclases contain two conserved regions, C1 and C2, which are responsible for forskolin- and G-protein-stimulated catalysis., The structure of the C2 catalytic region of type II rat adenylyl cyclase, has an alpha/beta class fold in a wreath-like dimer, which has a central, cleft. Two forskolin molecules bind in hydrophobic pockets at the ends of, cleft. The central part of the cleft is lined by charged residues, implicated in ATP binding. Forskolin appears to activate adenylyl cyclase, by promoting the assembly of the active dimer and by direct interaction, within the catalytic cleft. Other adenylyl cyclase regulators act at the, dimer interface or on a flexible C-terminal region.
About this Structure
1AB8 is a Single protein structure of sequence from Rattus norvegicus with FOK as ligand. Active as Adenylate cyclase, with EC number 4.6.1.1 Full crystallographic information is available from OCA.
Reference
Structure of the adenylyl cyclase catalytic core., Zhang G, Liu Y, Ruoho AE, Hurley JH, Nature. 1997 Mar 20;386(6622):247-53. PMID:9069282
Page seeded by OCA on Tue Nov 20 10:44:02 2007
