2vlk

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[[Image:2vlk.jpg|left|200px]]
[[Image:2vlk.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2vlk |SIZE=350|CAPTION= <scene name='initialview01'>2vlk</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2vlk", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|DOMAIN=
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{{STRUCTURE_2vlk| PDB=2vlk | SCENE= }}
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|RELATEDENTRY=[[2vlr|2VLR]], [[2vll|2VLL]], [[2vlm|2VLM]], [[2vlj|2VLJ]], [[1uqs|1UQS]], [[1bd2|1BD2]], [[2ak4|2AK4]], [[1ypz|1YPZ]], [[1im3|1IM3]], [[1uxw|1UXW]], [[1i7u|1I7U]], [[1c16|1C16]], [[1hsa|1HSA]], [[2axf|2AXF]], [[1gzp|1GZP]], [[2bnq|2BNQ]], [[1w72|1W72]], [[2jcc|2JCC]], [[2bck|2BCK]], [[1de4|1DE4]], [[1n2r|1N2R]], [[1exu|1EXU]], [[1qrn|1QRN]], [[2hla|2HLA]], [[1mhe|1MHE]], [[1im9|1IM9]], [[1eez|1EEZ]], [[1jht|1JHT]], [[1qqd|1QQD]], [[1qr1|1QR1]], [[1zs8|1ZS8]], [[1hla|1HLA]], [[1jgd|1JGD]], [[1i1y|1I1Y]], [[1vgk|1VGK]], [[1age|1AGE]], [[1ur7|1UR7]], [[1hhg|1HHG]], [[1s9x|1S9X]], [[1a9e|1A9E]], [[1duz|1DUZ]], [[2clr|2CLR]], [[3hla|3HLA]], [[1m05|1M05]], [[1tvb|1TVB]], [[2v2w|2V2W]], [[1onq|1ONQ]], [[1a1n|1A1N]], [[1lp9|1LP9]], [[1zsd|1ZSD]], [[1m6o|1M6O]], [[2bsu|2BSU]], [[1hhk|1HHK]], [[1zt4|1ZT4]], [[1hsb|1HSB]], [[1x7q|1X7Q]], [[1ce6|1CE6]], [[1py4|1PY4]], [[1syv|1SYV]], [[2j8u|2J8U]], [[1sys|1SYS]], [[1ogt|1OGT]], [[1cg9|1CG9]], [[1p7q|1P7Q]], [[1q94|1Q94]], [[1jnj|1JNJ]], [[1agb|1AGB]], [[2d31|2D31]], [[1aqd|1AQD]], [[1xz0|1XZ0]], [[1lds|1LDS]], [[1hhh|1HHH]], [[1tvh|1TVH]], [[1xr8|1XR8]], [[2bss|2BSS]], [[1a1m|1A1M]], [[1e28|1E28]], [[2v2x|2V2X]], [[1xr9|1XR9]], [[2gj6|2GJ6]], [[1efx|1EFX]], [[1qlf|1QLF]], [[2av1|2AV1]], [[1tmc|1TMC]], [[1qsf|1QSF]], [[1duy|1DUY]], [[1jge|1JGE]], [[1kpr|1KPR]], [[2hjl|2HJL]], [[1qew|1QEW]], [[1w0v|1W0V]], [[1k5n|1K5N]], [[1ao7|1AO7]], [[2bnr|2BNR]], [[1xh3|1XH3]], [[2bst|2BST]], [[1mi5|1MI5]], [[2h26|2H26]], [[1s9y|1S9Y]], [[1a1o|1A1O]], [[1agf|1AGF]], [[2a83|2A83]], [[1oga|1OGA]], [[2f8o|2F8O]], [[2bsv|2BSV]], [[2cii|2CII]], [[1i7r|1I7R]], [[1jf1|1JF1]], [[2c7u|2C7U]], [[2f74|2F74]], [[1e27|1E27]], [[1w0w|1W0W]], [[1gzq|1GZQ]], [[1uxs|1UXS]], [[1akj|1AKJ]], [[2hjk|2HJK]], [[2vb5|2VB5]], [[1agd|1AGD]], [[1r3h|1R3H]], [[1eey|1EEY]], [[1i7t|1I7T]], [[1i4f|1I4F]], [[1ydp|1YDP]], [[2bsr|2BSR]], [[1b0g|1B0G]], [[1b0r|1B0R]], [[1of2|1OF2]], [[1hhi|1HHI]], [[1qse|1QSE]], [[1a9b|1A9B]], [[2axg|2AXG]], [[2bvq|2BVQ]], [[1agc|1AGC]], [[1hhj|1HHJ]], [[1qvo|1QVO]], [[1s9w|1S9W]], [[1ktl|1KTL]], [[1a6z|1A6Z]], [[2cik|2CIK]], [[2uwe|2UWE]], [[1i1f|1I1F]], [[2av7|2AV7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vlk OCA], [http://www.ebi.ac.uk/pdbsum/2vlk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2vlk RCSB]</span>
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}}
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'''THE STRUCTURAL DYNAMICS AND ENERGETICS OF AN IMMUNODOMINANT T-CELL RECEPTOR ARE PROGRAMMED BY ITS VBETA DOMAIN'''
'''THE STRUCTURAL DYNAMICS AND ENERGETICS OF AN IMMUNODOMINANT T-CELL RECEPTOR ARE PROGRAMMED BY ITS VBETA DOMAIN'''
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[[Category: Merwe, A Van Der.]]
[[Category: Merwe, A Van Der.]]
[[Category: Stewart-Jones, G.]]
[[Category: Stewart-Jones, G.]]
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[[Category: complex]]
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[[Category: Complex]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: flu]]
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[[Category: Flu]]
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[[Category: glycation]]
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[[Category: Glycation]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: host-virus interaction]]
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[[Category: Host-virus interaction]]
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[[Category: immune response]]
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[[Category: Immune response]]
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[[Category: immune system/receptor/complex]]
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[[Category: Immune system/receptor/complex]]
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[[Category: immunodominance]]
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[[Category: Immunodominance]]
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[[Category: immunoglobulin domain]]
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[[Category: Immunoglobulin domain]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: mhc i]]
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[[Category: Mhc i]]
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[[Category: peptide]]
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[[Category: Peptide]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: pyrrolidone carboxylic acid]]
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[[Category: Pyrrolidone carboxylic acid]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: secreted]]
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[[Category: Secreted]]
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[[Category: t-cell]]
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[[Category: T-cell]]
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[[Category: tcr]]
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[[Category: Tcr]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: ubl conjugation]]
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[[Category: Ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:59:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:13:27 2008''
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Revision as of 15:59, 4 May 2008

Image:2vlk.jpg

Template:STRUCTURE 2vlk

THE STRUCTURAL DYNAMICS AND ENERGETICS OF AN IMMUNODOMINANT T-CELL RECEPTOR ARE PROGRAMMED BY ITS VBETA DOMAIN


Overview

Immunodominant and public T cell receptor (TCR) usage is relatively common in many viral diseases yet surprising in the context of the large naive TCR repertoire. We examined the highly conserved Vbeta17:Valpha10.2 JM22 T cell response to the influenza matrix peptide (58-66)-HLA-A( *)0201 (HLA-A2-flu) through extensive kinetic, thermodynamic, and structural analyses. We found several conformational adjustments that accompany JM22-HLA-A2-flu binding and identified a binding "hotspot" within the Vbeta domain of the TCR. Within this hotspot, key germline-encoded CDR1 and CDR2 loop residues and a crucial but commonly coded residue in the hypervariable region of CDR3 provide the basis for the substantial bias in the selection of the germline-encoded Vbeta17 domain. The chances of having a substantial number of T cells in the naive repertoire that have HLA-A2-flu-specific Vbeta17 receptors may consequently be relatively high, thus explaining the immunodominant usage of this clonotype.

About this Structure

2VLK is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain., Ishizuka J, Stewart-Jones GB, van der Merwe A, Bell JI, McMichael AJ, Jones EY, Immunity. 2008 Feb;28(2):171-82. PMID:18275829 Page seeded by OCA on Sun May 4 18:59:39 2008

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OCA

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