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1acf
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(New page: 200px<br /><applet load="1acf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1acf, resolution 2.0Å" /> '''ACANTHAMOEBA CASTELLA...)
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Revision as of 08:38, 20 November 2007
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ACANTHAMOEBA CASTELLANII PROFILIN IB
Overview
We determined the structures of Acanthamoeba profilin I and profilin II by, x-ray crystallography at resolutions of 2.0 and 2.8 A, respectively. The, polypeptide folds and the actin-binding surfaces of the amoeba profilins, are very similar to those of bovine and human profilins. The electrostatic, potential surfaces of the two Acanthamoeba isoforms differ. Two areas of, high positive potential on the surface of profilin II are candidate, binding sites for phosphatidylinositol phosphates. The proximity of these, sites to the actin binding site provides an explanation for the, competition between actin and lipids for binding profilin.
About this Structure
1ACF is a Single protein structure of sequence from Acanthamoeba castellanii. Full crystallographic information is available from OCA.
Reference
X-ray structures of isoforms of the actin-binding protein profilin that differ in their affinity for phosphatidylinositol phosphates., Fedorov AA, Magnus KA, Graupe MH, Lattman EE, Pollard TD, Almo SC, Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8636-40. PMID:8078936
Page seeded by OCA on Tue Nov 20 10:45:16 2007
