2z1c

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[[Image:2z1c.jpg|left|200px]]
[[Image:2z1c.jpg|left|200px]]
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{{Structure
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|PDB= 2z1c |SIZE=350|CAPTION= <scene name='initialview01'>2z1c</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2z1c", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= hypC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=311400 Thermococcus kodakarensis])
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|DOMAIN=
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{{STRUCTURE_2z1c| PDB=2z1c | SCENE= }}
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|RELATEDENTRY=[[2z1d|2Z1D]], [[2z1e|2Z1E]], [[2z1f|2Z1F]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z1c OCA], [http://www.ebi.ac.uk/pdbsum/2z1c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z1c RCSB]</span>
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'''Crystal structure of HypC from Thermococcus kodakaraensis KOD1'''
'''Crystal structure of HypC from Thermococcus kodakaraensis KOD1'''
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[[Category: Miki, K.]]
[[Category: Miki, K.]]
[[Category: Watanabe, S.]]
[[Category: Watanabe, S.]]
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[[Category: [nife] hydrogenase maturation]]
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[[Category: Ob-fold]]
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[[Category: ob-fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:49:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:17:21 2008''
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Revision as of 16:49, 4 May 2008

Image:2z1c.jpg

Template:STRUCTURE 2z1c

Crystal structure of HypC from Thermococcus kodakaraensis KOD1


Overview

[NiFe] hydrogenase maturation proteins HypC, HypD, and HypE catalyze the insertion and cyanation of the iron center of [NiFe] hydrogenases by an unknown mechanism. We have determined the crystal structures of HypC, HypD, and HypE from Thermococcus kodakaraensis KOD1 at 1.8 A, 2.07 A, and 1.55 A resolution, respectively. The structure of HypD reveals its probable iron binding and active sites for cyanation. An extended conformation of each conserved motif of HypC and HypE allows the essential cysteine residues of both proteins to interact with the active site of HypD. Furthermore, the C-terminal tail of HypE is shown to exist in an ATP-dependent dynamic equilibrium between outward and inward conformations. Unexpectedly, the [4Fe-4S] cluster environment of HypD is quite similar to that of ferredoxin:thioredoxin reductase (FTR), indicating the existence of a redox cascade similar to the FTR system. These results suggest a cyanation reaction mechanism via unique thiol redox signaling in the HypCDE complex.

About this Structure

2Z1C is a Single protein structure of sequence from Thermococcus kodakarensis. Full crystallographic information is available from OCA.

Reference

Crystal structures of [NiFe] hydrogenase maturation proteins HypC, HypD, and HypE: insights into cyanation reaction by thiol redox signaling., Watanabe S, Matsumi R, Arai T, Atomi H, Imanaka T, Miki K, Mol Cell. 2007 Jul 6;27(1):29-40. PMID:17612488 Page seeded by OCA on Sun May 4 19:49:18 2008

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