1h3f
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1h3f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h3f, resolution 2.00Å" /> '''TYROSYL-TRNA SYNTHE...)
Next diff →
Revision as of 17:15, 29 October 2007
|
TYROSYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH TYROSINOL
Overview
Bacterial tyrosyl-tRNA synthetases (TyrRS) possess a flexibly linked, C-terminal domain of approximately 80 residues, which has hitherto been, disordered in crystal structures of the enzyme. We have determined the, structure of Thermus thermophilus TyrRS at 2.0 A resolution in a crystal, form in which the C-terminal domain is ordered, and confirm that the fold, is similar to part of the C-terminal domain of ribosomal protein S4. We, have also determined the structure at 2.9 A resolution of the complex of, T.thermophilus TyrRS with cognate tRNA(tyr)(G Psi A). In this structure, the C-terminal domain binds between the characteristic long variable arm, of the tRNA and the anti-codon stem, thus recognizing the unique shape of, the tRNA. The anticodon bases have a novel conformation with A-36 ... [(full description)]
About this Structure
1H3F is a [Single protein] structure of sequence from [Thermus thermophilus] with SO4 and TYB as [ligands]. Full crystallographic information is available from [OCA].
Reference
Class I tyrosyl-tRNA synthetase has a class II mode of cognate tRNA recognition., Yaremchuk A, Kriklivyi I, Tukalo M, Cusack S, EMBO J. 2002 Jul 15;21(14):3829-40. PMID:12110594[[Category: atp + l-tyrosine + trna(tyr)->amp + ppi + l-tyrosyl-trna(ty class i aminoacyl-trna synthetase]]
Page seeded by OCA on Mon Oct 29 19:20:15 2007
