2z3r

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[[Image:2z3r.gif|left|200px]]
[[Image:2z3r.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2z3r |SIZE=350|CAPTION= <scene name='initialview01'>2z3r</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2z3r", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= IL-15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), IL-15RA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2z3r| PDB=2z3r | SCENE= }}
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|RELATEDENTRY=[[2z2q|2Z2Q]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z3r OCA], [http://www.ebi.ac.uk/pdbsum/2z3r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z3r RCSB]</span>
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'''Crystal structure of the IL-15/IL-15Ra complex'''
'''Crystal structure of the IL-15/IL-15Ra complex'''
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[[Category: Ikemizu, S.]]
[[Category: Ikemizu, S.]]
[[Category: Yamagata, Y.]]
[[Category: Yamagata, Y.]]
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[[Category: cytokine/cytokine receptor complex]]
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[[Category: Cytokine/cytokine receptor complex]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:55:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:18:16 2008''
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Revision as of 16:55, 4 May 2008

Image:2z3r.gif

Template:STRUCTURE 2z3r

Crystal structure of the IL-15/IL-15Ra complex


Overview

Interleukin 15 (IL-15) and IL-2, which promote the survival of memory CD8(+) T cells and regulatory T cells, respectively, bind receptor complexes that share beta- and gamma-signaling subunits. Receptor specificity is provided by unique, nonsignaling alpha-subunits. Whereas IL-2 receptor-alpha (IL-2Ralpha) is expressed together in cis with the beta- and gamma-subunits on T cells and B cells, IL-15Ralpha is expressed in trans on antigen-presenting cells. Here we present a 1.85-A crystal structure of the human IL-15-IL-15Ralpha complex. The structure provides insight into the molecular basis of the specificity of cytokine recognition and emphasizes the importance of water in generating this very high-affinity complex. Despite very low IL-15-IL-2 sequence homology and distinct receptor architecture, the topologies of the IL-15-IL-15Ralpha and IL-2-IL-2Ralpha complexes are very similar. Our data raise the possibility that IL-2, like IL-15, might be capable of being presented in trans in the context of its unique receptor alpha-chain.

About this Structure

2Z3R is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans., Chirifu M, Hayashi C, Nakamura T, Toma S, Shuto T, Kai H, Yamagata Y, Davis SJ, Ikemizu S, Nat Immunol. 2007 Sep;8(9):1001-7. Epub 2007 Jul 22. PMID:17643103 Page seeded by OCA on Sun May 4 19:55:31 2008

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