2z65

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2z65.jpg|left|200px]]
[[Image:2z65.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2z65 |SIZE=350|CAPTION= <scene name='initialview01'>2z65</scene>, resolution 2.70&Aring;
+
The line below this paragraph, containing "STRUCTURE_2z65", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=E55:3-O-DECYL-2-DEOXY-6-O-{2-DEOXY-3-O-[(3R)-3-METHOXYDECYL]-6-O-METHYL-2-[(11Z)-OCTADEC-11-ENOYLAMINO]-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSYL}-2-[(3-OXOTETRADECANOYL)AMINO]-1-O-PHOSPHONO-ALPHA-D-GLUCOPYRANOSE'>E55</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= TLR4, VLRB.61 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Homo sapiens, Eptatretus burgeri]), MD-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2z65| PDB=2z65 | SCENE= }}
-
|RELATEDENTRY=[[2z62|2Z62]], [[2z63|2Z63]], [[2z64|2Z64]], [[2z66|2Z66]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z65 OCA], [http://www.ebi.ac.uk/pdbsum/2z65 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z65 RCSB]</span>
+
-
}}
+
'''Crystal structure of the human TLR4 TV3 hybrid-MD-2-Eritoran complex'''
'''Crystal structure of the human TLR4 TV3 hybrid-MD-2-Eritoran complex'''
Line 29: Line 26:
[[Category: Lee, J O.]]
[[Category: Lee, J O.]]
[[Category: Park, B S.]]
[[Category: Park, B S.]]
-
[[Category: e5564]]
+
[[Category: E5564]]
-
[[Category: eritoran]]
+
[[Category: Eritoran]]
-
[[Category: glycoprotein]]
+
[[Category: Glycoprotein]]
-
[[Category: immune response]]
+
[[Category: Immune response]]
-
[[Category: immune system]]
+
[[Category: Immune system]]
-
[[Category: inflammatory response]]
+
[[Category: Inflammatory response]]
-
[[Category: innate immunity]]
+
[[Category: Innate immunity]]
-
[[Category: leucine-rich repeat]]
+
[[Category: Leucine-rich repeat]]
-
[[Category: lp]]
+
[[Category: Lp]]
-
[[Category: md-2]]
+
[[Category: Md-2]]
-
[[Category: membrane]]
+
[[Category: Membrane]]
-
[[Category: polymorphism]]
+
[[Category: Polymorphism]]
-
[[Category: secreted]]
+
[[Category: Secreted]]
-
[[Category: tlr4]]
+
[[Category: Tlr4]]
-
[[Category: toll-like receptor]]
+
[[Category: Toll-like receptor]]
-
[[Category: transmembrane]]
+
[[Category: Transmembrane]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 19:59:40 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:18:56 2008''
+

Revision as of 16:59, 4 May 2008

Image:2z65.jpg

Template:STRUCTURE 2z65

Crystal structure of the human TLR4 TV3 hybrid-MD-2-Eritoran complex


Overview

TLR4 and MD-2 form a heterodimer that recognizes LPS (lipopolysaccharide) from Gram-negative bacteria. Eritoran is an analog of LPS that antagonizes its activity by binding to the TLR4-MD-2 complex. We determined the structure of the full-length ectodomain of the mouse TLR4 and MD-2 complex. We also produced a series of hybrids of human TLR4 and hagfish VLR and determined their structures with and without bound MD-2 and Eritoran. TLR4 is an atypical member of the LRR family and is composed of N-terminal, central, and C-terminal domains. The beta sheet of the central domain shows unusually small radii and large twist angles. MD-2 binds to the concave surface of the N-terminal and central domains. The interaction with Eritoran is mediated by a hydrophobic internal pocket in MD-2. Based on structural analysis and mutagenesis experiments on MD-2 and TLR4, we propose a model of TLR4-MD-2 dimerization induced by LPS.

About this Structure

2Z65 is a Protein complex structure of sequences from Homo sapiens and Homo sapiens, eptatretus burgeri. Full crystallographic information is available from OCA.

Reference

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran., Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, Lee JO, Cell. 2007 Sep 7;130(5):906-17. PMID:17803912 Page seeded by OCA on Sun May 4 19:59:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2z65"
Personal tools