2z6g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2z6g.jpg|left|200px]]
[[Image:2z6g.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2z6g |SIZE=350|CAPTION= <scene name='initialview01'>2z6g</scene>, resolution 3.40&Aring;
+
The line below this paragraph, containing "STRUCTURE_2z6g", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00020 ARM], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00185 ARM]</span>
+
{{STRUCTURE_2z6g| PDB=2z6g | SCENE= }}
-
|RELATEDENTRY=[[2z6h|2Z6H]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6g OCA], [http://www.ebi.ac.uk/pdbsum/2z6g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z6g RCSB]</span>
+
-
}}
+
'''Crystal Structure of a Full-Length Zebrafish Beta-Catenin'''
'''Crystal Structure of a Full-Length Zebrafish Beta-Catenin'''
Line 31: Line 28:
[[Category: Xu, W.]]
[[Category: Xu, W.]]
[[Category: Zheng, J.]]
[[Category: Zheng, J.]]
-
[[Category: beta-catenin]]
+
[[Category: Beta-catenin]]
-
[[Category: cell adhesion]]
+
[[Category: Cell adhesion]]
-
[[Category: crystal structure]]
+
[[Category: Crystal structure]]
-
[[Category: full-length]]
+
[[Category: Full-length]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:00:08 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:18:59 2008''
+

Revision as of 17:00, 4 May 2008

Image:2z6g.jpg

Template:STRUCTURE 2z6g

Crystal Structure of a Full-Length Zebrafish Beta-Catenin


Overview

beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix that packs on the C-terminal end of the armadillo repeat domain, and thus forms part of the beta-catenin superhelical core. The existence of this helix redefines our view of interactions of beta-catenin with some of its critical partners, including ICAT and Chibby, which may form extensive interactions with this C-terminal domain alpha helix. Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner.

About this Structure

2Z6G is a Single protein structure of sequence from Danio rerio. Full crystallographic information is available from OCA.

Reference

Crystal Structure of a Full-Length beta-Catenin., Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W, Structure. 2008 Mar;16(3):478-87. PMID:18334222 Page seeded by OCA on Sun May 4 20:00:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2z6g"
Personal tools