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2z6h

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[[Image:2z6h.jpg|left|200px]]
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{{Structure
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|PDB= 2z6h |SIZE=350|CAPTION= <scene name='initialview01'>2z6h</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_2z6h", creates the "Structure Box" on the page.
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00020 ARM], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=smart00185 ARM]</span>
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{{STRUCTURE_2z6h| PDB=2z6h | SCENE= }}
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|RELATEDENTRY=[[2z6g|2Z6G]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6h OCA], [http://www.ebi.ac.uk/pdbsum/2z6h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z6h RCSB]</span>
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'''Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain'''
'''Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain'''
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[[Category: Xu, W.]]
[[Category: Xu, W.]]
[[Category: Zheng, J.]]
[[Category: Zheng, J.]]
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[[Category: activator]]
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[[Category: Activator]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: beta-catenin]]
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[[Category: Beta-catenin]]
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[[Category: c-terminal domain]]
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[[Category: C-terminal domain]]
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[[Category: cell adhesion]]
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[[Category: Cell adhesion]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Polymorphism]]
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[[Category: structural protein]]
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[[Category: Structural protein]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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[[Category: ubl conjugation]]
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[[Category: Ubl conjugation]]
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[[Category: wnt signaling pathway]]
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[[Category: Wnt signaling pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:00:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:19:07 2008''
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Revision as of 17:00, 4 May 2008

Image:2z6h.jpg

Template:STRUCTURE 2z6h

Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain


Overview

beta-catenin plays essential roles in cell adhesion and Wnt signaling, while deregulation of beta-catenin is associated with multiple diseases including cancers. Here, we report the crystal structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains. Our structures reveal that the N-terminal region of the C-terminal domain, a key component of the C-terminal transactivation domain, forms a long alpha helix that packs on the C-terminal end of the armadillo repeat domain, and thus forms part of the beta-catenin superhelical core. The existence of this helix redefines our view of interactions of beta-catenin with some of its critical partners, including ICAT and Chibby, which may form extensive interactions with this C-terminal domain alpha helix. Our crystallographic and NMR studies also suggest that the unstructured N-terminal and C-terminal tails interact with the ordered armadillo repeat domain in a dynamic and variable manner.

About this Structure

2Z6H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal Structure of a Full-Length beta-Catenin., Xing Y, Takemaru K, Liu J, Berndt JD, Zheng JJ, Moon RT, Xu W, Structure. 2008 Mar;16(3):478-87. PMID:18334222 Page seeded by OCA on Sun May 4 20:00:14 2008

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