2z6o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2z6o.gif|left|200px]]
[[Image:2z6o.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2z6o |SIZE=350|CAPTION= <scene name='initialview01'>2z6o</scene>, resolution 1.60&Aring;
+
The line below this paragraph, containing "STRUCTURE_2z6o", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2z6o| PDB=2z6o | SCENE= }}
-
|RELATEDENTRY=[[2z6p|2Z6P]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6o OCA], [http://www.ebi.ac.uk/pdbsum/2z6o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z6o RCSB]</span>
+
-
}}
+
'''Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1'''
'''Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1'''
Line 36: Line 33:
[[Category: Tatsumi, K.]]
[[Category: Tatsumi, K.]]
[[Category: Yamane, T.]]
[[Category: Yamane, T.]]
-
[[Category: ligase]]
+
[[Category: Ligase]]
-
[[Category: polymorphism]]
+
[[Category: Polymorphism]]
-
[[Category: ubiquitin]]
+
[[Category: Ubiquitin]]
-
[[Category: ubl]]
+
[[Category: Ubl]]
-
[[Category: ubl conjugation pathway]]
+
[[Category: Ubl conjugation pathway]]
-
[[Category: ufc1]]
+
[[Category: Ufc1]]
-
[[Category: ufm1]]
+
[[Category: Ufm1]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:00:27 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:19:03 2008''
+

Revision as of 17:00, 4 May 2008

Image:2z6o.gif

Template:STRUCTURE 2z6o

Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1


Overview

Ubiquitin and ubiquitin-like protein-conjugating enzymes play central roles in posttranslational modification processes. The ubiquitin-fold modifier 1 (Ufm1), one of a variety of ubiquitin-like modifiers, is covalently attached to target proteins via Uba5 and Ufm1-conjugating enzyme 1 (Ufc1), which are analogous to the E1 and E2 ubiquitylation enzymes. As Ufm1-related proteins are conserved in metazoa and plants, the Ufm1 system likely plays important roles in various multicellular organisms. Herein, we report the X-ray structure of human Ufc1 determined at 1.6 A resolution. The Ufc1 structure comprises a canonical E2 domain and an additional N-terminal domain. The Uba5 binding site on Ufc1 was assigned by structural comparison of Ufc1 and Ubc12 and related mutational analyses. In addition, we show that the N-terminal unique domain of Ufc1 contributes to thermal stability.

About this Structure

2Z6O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of Ufc1, the Ufm1-conjugating enzyme., Mizushima T, Tatsumi K, Ozaki Y, Kawakami T, Suzuki A, Ogasahara K, Komatsu M, Kominami E, Tanaka K, Yamane T, Biochem Biophys Res Commun. 2007 Nov 3;362(4):1079-84. Epub 2007 Aug 30. PMID:17825256 Page seeded by OCA on Sun May 4 20:00:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2z6o"
Personal tools