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2z6p

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[[Image:2z6p.gif|left|200px]]
[[Image:2z6p.gif|left|200px]]
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{{Structure
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|PDB= 2z6p |SIZE=350|CAPTION= <scene name='initialview01'>2z6p</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2z6p", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= UFC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2z6p| PDB=2z6p | SCENE= }}
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|RELATEDENTRY=[[2z6o|2Z6O]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z6p OCA], [http://www.ebi.ac.uk/pdbsum/2z6p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z6p RCSB]</span>
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'''Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1'''
'''Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1'''
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[[Category: Tatsumi, K.]]
[[Category: Tatsumi, K.]]
[[Category: Yamane, T.]]
[[Category: Yamane, T.]]
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[[Category: ligase]]
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[[Category: Ligase]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: ubiquitin]]
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[[Category: Ubiquitin]]
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[[Category: ubl]]
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[[Category: Ubl]]
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[[Category: ubl conjugation pathway]]
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[[Category: Ubl conjugation pathway]]
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[[Category: ufc1]]
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[[Category: Ufc1]]
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[[Category: ufm1]]
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[[Category: Ufm1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:00:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:19:02 2008''
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Revision as of 17:00, 4 May 2008

Image:2z6p.gif

Template:STRUCTURE 2z6p

Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1


Overview

Ubiquitin and ubiquitin-like protein-conjugating enzymes play central roles in posttranslational modification processes. The ubiquitin-fold modifier 1 (Ufm1), one of a variety of ubiquitin-like modifiers, is covalently attached to target proteins via Uba5 and Ufm1-conjugating enzyme 1 (Ufc1), which are analogous to the E1 and E2 ubiquitylation enzymes. As Ufm1-related proteins are conserved in metazoa and plants, the Ufm1 system likely plays important roles in various multicellular organisms. Herein, we report the X-ray structure of human Ufc1 determined at 1.6 A resolution. The Ufc1 structure comprises a canonical E2 domain and an additional N-terminal domain. The Uba5 binding site on Ufc1 was assigned by structural comparison of Ufc1 and Ubc12 and related mutational analyses. In addition, we show that the N-terminal unique domain of Ufc1 contributes to thermal stability.

About this Structure

2Z6P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of Ufc1, the Ufm1-conjugating enzyme., Mizushima T, Tatsumi K, Ozaki Y, Kawakami T, Suzuki A, Ogasahara K, Komatsu M, Kominami E, Tanaka K, Yamane T, Biochem Biophys Res Commun. 2007 Nov 3;362(4):1079-84. Epub 2007 Aug 30. PMID:17825256 Page seeded by OCA on Sun May 4 20:00:35 2008

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