2z9q

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[[Image:2z9q.gif|left|200px]]
[[Image:2z9q.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2z9q |SIZE=350|CAPTION= <scene name='initialview01'>2z9q</scene>
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The line below this paragraph, containing "STRUCTURE_2z9q", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5&#39;-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=2MG:2N-METHYLGUANOSINE-5&#39;-MONOPHOSPHATE'>2MG</scene>, <scene name='pdbligand=5MC:5-METHYLCYTIDINE-5&#39;-MONOPHOSPHATE'>5MC</scene>, <scene name='pdbligand=5MU:5-METHYLURIDINE+5&#39;-MONOPHOSPHATE'>5MU</scene>, <scene name='pdbligand=7MG:7N-METHYL-8-HYDROGUANOSINE-5&#39;-MONOPHOSPHATE'>7MG</scene>, <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=H2U:5,6-DIHYDROURIDINE-5&#39;-MONOPHOSPHATE'>H2U</scene>, <scene name='pdbligand=M2G:N2-DIMETHYLGUANOSINE-5&#39;-MONOPHOSPHATE'>M2G</scene>, <scene name='pdbligand=OMC:O2&#39;-METHYLYCYTIDINE-5&#39;-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2&#39;-METHYLGUANOSINE-5&#39;-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5&#39;-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=YYG:4-(3-[5-O-PHOSPHONORIBOFURANOSYL]-4,6-DIMETHYL-8-OXO-4,8-DIHYDRO-3H-1,3,4,5,7A-PENTAAZA-S-INDACEN-YLAMINO-BUTYRIC+ACID+METHYL+ESTER'>YYG</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2z9q| PDB=2z9q | SCENE= }}
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|RELATEDENTRY=[[1ttt|1TTT]], [[1pn6|1PN6]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2z9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z9q OCA], [http://www.ebi.ac.uk/pdbsum/2z9q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2z9q RCSB]</span>
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}}
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'''Transfer RNA in the hybrid P/E state'''
'''Transfer RNA in the hybrid P/E state'''
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[[Category: Frank, J.]]
[[Category: Frank, J.]]
[[Category: Li, W.]]
[[Category: Li, W.]]
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[[Category: distorted anticodon-stem-loop]]
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[[Category: Distorted anticodon-stem-loop]]
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[[Category: rna]]
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[[Category: Rna]]
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[[Category: twisted cca arm]]
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[[Category: Twisted cca arm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:04:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:19:42 2008''
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Revision as of 17:04, 4 May 2008

Image:2z9q.gif

Template:STRUCTURE 2z9q

Transfer RNA in the hybrid P/E state


Overview

During the ribosomal translocation, the binding of elongation factor G (EF-G) to the pretranslocational ribosome leads to a ratchet-like rotation of the 30S subunit relative to the 50S subunit in the direction of the mRNA movement. By means of cryo-electron microscopy we observe that this rotation is accompanied by a 20 A movement of the L1 stalk of the 50S subunit, implying that this region is involved in the translocation of deacylated tRNAs from the P to the E site. These ribosomal motions can occur only when the P-site tRNA is deacylated. Prior to peptidyl-transfer to the A-site tRNA or peptide removal, the presence of the charged P-site tRNA locks the ribosome and prohibits both of these motions.

About this Structure

2Z9Q is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Locking and unlocking of ribosomal motions., Valle M, Zavialov A, Sengupta J, Rawat U, Ehrenberg M, Frank J, Cell. 2003 Jul 11;114(1):123-34. PMID:12859903 Page seeded by OCA on Sun May 4 20:04:25 2008

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