2zb1

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[[Image:2zb1.jpg|left|200px]]
[[Image:2zb1.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2zb1 |SIZE=350|CAPTION= <scene name='initialview01'>2zb1</scene>, resolution 2.500&Aring;
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The line below this paragraph, containing "STRUCTURE_2zb1", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GK4:N-(CYCLOPROPYLMETHYL)-2&#39;-METHYL-5&#39;-(5-METHYL-1,3,4-OXADIAZOL-2-YL)BIPHENYL-4-CARBOXAMIDE'>GK4</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2zb1| PDB=2zb1 | SCENE= }}
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|RELATEDENTRY=[[2zaz|2ZAZ]], [[2zb0|2ZB0]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zb1 OCA], [http://www.ebi.ac.uk/pdbsum/2zb1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2zb1 RCSB]</span>
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}}
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'''Crystal structure of P38 in complex with biphenyl amide inhibitor'''
'''Crystal structure of P38 in complex with biphenyl amide inhibitor'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Somers, D O.]]
[[Category: Somers, D O.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: map kinase]]
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[[Category: Map kinase]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: nucleus]]
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[[Category: Nucleus]]
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[[Category: p38]]
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[[Category: P38]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: serine/threonine protein kinase]]
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[[Category: Serine/threonine protein kinase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:06:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:20:01 2008''
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Revision as of 17:06, 4 May 2008

Image:2zb1.jpg

Template:STRUCTURE 2zb1

Crystal structure of P38 in complex with biphenyl amide inhibitor


Overview

The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.

About this Structure

2ZB1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306 Page seeded by OCA on Sun May 4 20:06:20 2008

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OCA

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