365d
From Proteopedia
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[[Image:365d.gif|left|200px]] | [[Image:365d.gif|left|200px]] | ||
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| - | + | {{STRUCTURE_365d| PDB=365d | SCENE= }} | |
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'''STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE''' | '''STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=365D OCA]. | |
==Reference== | ==Reference== | ||
Structural basis for G.C recognition in the DNA minor groove., Kielkopf CL, Baird EE, Dervan PB, Rees DC, Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9461074 9461074] | Structural basis for G.C recognition in the DNA minor groove., Kielkopf CL, Baird EE, Dervan PB, Rees DC, Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9461074 9461074] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Baird, E E.]] | [[Category: Baird, E E.]] | ||
[[Category: Dervan, P B.]] | [[Category: Dervan, P B.]] | ||
[[Category: Kielkopf, C L.]] | [[Category: Kielkopf, C L.]] | ||
[[Category: Rees, D C.]] | [[Category: Rees, D C.]] | ||
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| - | [[Category: | + | [[Category: Double helix]] |
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:17:29 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:17, 4 May 2008
STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE
Overview
Small molecules that target specific DNA sequences offer a potentially general approach for the regulation of gene expression. Pyrrole-imidazole polyamides represent the only class of synthetic small molecules that can bind predetermined DNA sequences with affinities and specificities comparable to DNA binding proteins. Antiparallel side-by-side pairings of two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C from C.G, and both from A.T/T.A base pairs. A high resolution X-ray crystal structure of a four-ring pyrrole-imidazole polyamide specifically bound as a dimer to a six-base pair predetermined DNA site reveals a structural framework of hydrogen bonds and interactions with the walls of the minor groove that underlies the pairing rules for DNA recognition.
About this Structure
Full crystallographic information is available from OCA.
Reference
Structural basis for G.C recognition in the DNA minor groove., Kielkopf CL, Baird EE, Dervan PB, Rees DC, Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:9461074 Page seeded by OCA on Sun May 4 20:17:29 2008
