3b31
From Proteopedia
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[[Image:3b31.jpg|left|200px]] | [[Image:3b31.jpg|left|200px]] | ||
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'''Crystal structure of domain III of the Cricket Paralysis Virus IRES RNA''' | '''Crystal structure of domain III of the Cricket Paralysis Virus IRES RNA''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 3B31 is a [[Protein complex]] structure | + | 3B31 is a [[Protein complex]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B31 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Pfingsten, J S.]] | [[Category: Pfingsten, J S.]] | ||
[[Category: Rambo, R P.]] | [[Category: Rambo, R P.]] | ||
| - | [[Category: | + | [[Category: Hybrid state]] |
| - | [[Category: | + | [[Category: Ire]] |
| - | [[Category: | + | [[Category: Rna structure]] |
| - | [[Category: | + | [[Category: Translation initiation]] |
| - | [[Category: | + | [[Category: Trna anticodon]] |
| - | [[Category: | + | [[Category: Trna mimicry]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:20:52 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 17:20, 4 May 2008
Crystal structure of domain III of the Cricket Paralysis Virus IRES RNA
Overview
Internal ribosome entry site (IRES) RNAs initiate protein synthesis in eukaryotic cells by a noncanonical cap-independent mechanism. IRESes are critical for many pathogenic viruses, but efforts to understand their function are complicated by the diversity of IRES sequences as well as by limited high-resolution structural information. The intergenic region (IGR) IRESes of the Dicistroviridae viruses are powerful model systems to begin to understand IRES function. Here we present the crystal structure of a Dicistroviridae IGR IRES domain that interacts with the ribosome's decoding groove. We find that this RNA domain precisely mimics the transfer RNA anticodon-messenger RNA codon interaction, and its modeled orientation on the ribosome helps explain translocation without peptide bond formation. When combined with a previous structure, this work completes the first high-resolution description of an IRES RNA and provides insight into how RNAs can manipulate complex biological machines.
About this Structure
3B31 is a Protein complex structure. Full crystallographic information is available from OCA.
Reference
tRNA-mRNA mimicry drives translation initiation from a viral IRES., Costantino DA, Pfingsten JS, Rambo RP, Kieft JS, Nat Struct Mol Biol. 2008 Jan;15(1):57-64. Epub 2007 Dec 23. PMID:18157151 Page seeded by OCA on Sun May 4 20:20:52 2008
