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3b3f

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[[Image:3b3f.gif|left|200px]]
[[Image:3b3f.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 3b3f |SIZE=350|CAPTION= <scene name='initialview01'>3b3f</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_3b3f", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= Carm1, Prmt4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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|DOMAIN=
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{{STRUCTURE_3b3f| PDB=3b3f | SCENE= }}
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|RELATEDENTRY=[[2oqb|2OQB]], [[3b3g|3B3G]], [[3b3j|3B3J]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b3f OCA], [http://www.ebi.ac.uk/pdbsum/3b3f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3b3f RCSB]</span>
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'''The 2.2 A crystal structure of the catalytic domain of coactivator-associated arginine methyl transferase I(CARM1,142-478), in complex with S-adenosyl homocysteine'''
'''The 2.2 A crystal structure of the catalytic domain of coactivator-associated arginine methyl transferase I(CARM1,142-478), in complex with S-adenosyl homocysteine'''
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[[Category: Moras, D.]]
[[Category: Moras, D.]]
[[Category: Troffer-Charlier, N.]]
[[Category: Troffer-Charlier, N.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: catalytic domain]]
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[[Category: Catalytic domain]]
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[[Category: chromatin regulator]]
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[[Category: Chromatin regulator]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: mrna processing]]
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[[Category: Mrna processing]]
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[[Category: mrna splicing]]
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[[Category: Mrna splicing]]
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[[Category: nucleus]]
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[[Category: Nucleus]]
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[[Category: protein arginine methyltransferase]]
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[[Category: Protein arginine methyltransferase]]
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[[Category: s-adenosyl-l-methionine]]
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[[Category: S-adenosyl-l-methionine]]
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[[Category: transcription]]
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[[Category: Transcription]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:21:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:22:42 2008''
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Revision as of 17:21, 4 May 2008

Image:3b3f.gif

Template:STRUCTURE 3b3f

The 2.2 A crystal structure of the catalytic domain of coactivator-associated arginine methyl transferase I(CARM1,142-478), in complex with S-adenosyl homocysteine


Overview

Coactivator-associated arginine methyltransferase 1 (CARM1), a protein arginine methyltransferase recruited by several transcription factors, methylates a large variety of proteins and plays a critical role in gene expression. We report, in this paper, four crystal structures of isolated modules of CARM1. The 1.7 A crystal structure of the N-terminal domain of CARM1 reveals an unexpected PH domain, a scaffold frequently found to regulate protein-protein interactions in a large variety of biological processes. Three crystal structures of the CARM1 catalytic module, two free and one cofactor-bound forms (refined at 2.55 A, 2.4 A and 2.2 A, respectively) reveal large structural modifications including disorder to order transition, helix to strand transition and active site modifications. The N-terminal and the C-terminal end of CARM1 catalytic module contain molecular switches that may inspire how CARM1 regulates its biological activities by protein-protein interactions.

About this Structure

3B3F is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Functional insights from structures of coactivator-associated arginine methyltransferase 1 domains., Troffer-Charlier N, Cura V, Hassenboehler P, Moras D, Cavarelli J, EMBO J. 2007 Oct 17;26(20):4391-401. Epub 2007 Sep 20. PMID:17882262 Page seeded by OCA on Sun May 4 20:21:29 2008

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