3b8k

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[[Image:3b8k.jpg|left|200px]]
[[Image:3b8k.jpg|left|200px]]
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{{Structure
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|PDB= 3b8k |SIZE=350|CAPTION= <scene name='initialview01'>3b8k</scene>
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The line below this paragraph, containing "STRUCTURE_3b8k", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= DLAT, DLTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_3b8k| PDB=3b8k | SCENE= }}
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|RELATEDENTRY=[[1eaa|1EAA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8k OCA], [http://www.ebi.ac.uk/pdbsum/3b8k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3b8k RCSB]</span>
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'''Structure of the Truncated Human Dihydrolipoyl Acetyltransferase (E2)'''
'''Structure of the Truncated Human Dihydrolipoyl Acetyltransferase (E2)'''
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[[Category: Yu, X.]]
[[Category: Yu, X.]]
[[Category: Zhou, Z H.]]
[[Category: Zhou, Z H.]]
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[[Category: central beta-sheet surrounded by five alpha-helice]]
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[[Category: Central beta-sheet surrounded by five alpha-helice]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:31:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:24:10 2008''
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Revision as of 17:31, 4 May 2008

Image:3b8k.jpg

Template:STRUCTURE 3b8k

Structure of the Truncated Human Dihydrolipoyl Acetyltransferase (E2)


Overview

Dihydrolipoyl acetyltransferase (E2) is the central component of pyruvate dehydrogenase complex (PDC), which converts pyruvate to acetyl-CoA. Structural comparison by cryo-electron microscopy (cryo-EM) of the human full-length and truncated E2 (tE2) cores revealed flexible linkers emanating from the edges of trimers of the internal catalytic domains. Using the secondary structure constraints revealed in our 8 A cryo-EM reconstruction and the prokaryotic tE2 atomic structure as a template, we derived a pseudo atomic model of human tE2. The active sites are conserved between prokaryotic tE2 and human tE2. However, marked structural differences are apparent in the hairpin domain and in the N-terminal helix connected to the flexible linker. These permutations away from the catalytic center likely impart structures needed to integrate a second component into the inner core and provide a sturdy base for the linker that holds the pyruvate dehydrogenase for access by the E2-bound regulatory kinase/phosphatase components in humans.

About this Structure

3B8K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains., Yu X, Hiromasa Y, Tsen H, Stoops JK, Roche TE, Zhou ZH, Structure. 2008 Jan;16(1):104-14. PMID:18184588 Page seeded by OCA on Sun May 4 20:31:13 2008

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