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3b8z

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[[Image:3b8z.jpg|left|200px]]
[[Image:3b8z.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3b8z |SIZE=350|CAPTION= <scene name='initialview01'>3b8z</scene>, resolution 1.400&Aring;
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The line below this paragraph, containing "STRUCTURE_3b8z", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=294:N-HYDROXY-4-({4-[4-(TRIFLUOROMETHYL)PHENOXY]PHENYL}SULFONYL)TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE'>294</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= ADAMTS5, ADAMTS11, ADMP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_3b8z| PDB=3b8z | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8z OCA], [http://www.ebi.ac.uk/pdbsum/3b8z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3b8z RCSB]</span>
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}}
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'''High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)'''
'''High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)'''
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[[Category: Tortorella, M D.]]
[[Category: Tortorella, M D.]]
[[Category: Williams, J M.]]
[[Category: Williams, J M.]]
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[[Category: alpha/beta]]
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[[Category: Alpha/beta]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:32:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:24:15 2008''
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Revision as of 17:32, 4 May 2008

Image:3b8z.jpg

Template:STRUCTURE 3b8z

High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)


Overview

Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan. The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor. A high resolution structure of an ADAMTS/aggrecanase protein provides an opportunity for the development of therapeutics to treat osteoarthritis.

About this Structure

3B8Z is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)., Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A, J Biol Chem. 2008 Jan 18;283(3):1501-7. Epub 2007 Nov 8. PMID:17991750 Page seeded by OCA on Sun May 4 20:32:03 2008

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