3bd0

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[[Image:3bd0.gif|left|200px]]
[[Image:3bd0.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 3bd0 |SIZE=350|CAPTION= <scene name='initialview01'>3bd0</scene>, resolution 3.010&Aring;
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The line below this paragraph, containing "STRUCTURE_3bd0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= MEMO1, C2orf4, NS5ATP7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_3bd0| PDB=3bd0 | SCENE= }}
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|RELATEDENTRY=[[3bcz|3BCZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bd0 OCA], [http://www.ebi.ac.uk/pdbsum/3bd0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bd0 RCSB]</span>
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}}
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'''Crystal structure of Memo, form II'''
'''Crystal structure of Memo, form II'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Qiu, C.]]
[[Category: Qiu, C.]]
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[[Category: alpha/beta structure]]
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[[Category: Alpha/beta structure]]
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[[Category: peptide binding protein]]
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[[Category: Peptide binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:39:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:25:14 2008''
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Revision as of 17:39, 4 May 2008

Image:3bd0.gif

Template:STRUCTURE 3bd0

Crystal structure of Memo, form II


Overview

Memo (mediator of ErbB2-driven cell motility) is a 297-amino-acid protein recently shown to co-precipitate with the C terminus of ErbB2 and be required for ErbB2-driven cell motility. Memo is not homologous to any known signaling proteins, and how it mediates ErbB2 signals is not known. To provide a molecular basis for understanding Memo function, we have determined and report here the 2.1A crystal structure of human Memo and show it be homologous to class III nonheme iron-dependent dioxygenases, a structural class that now includes a zinc-binding protein of unknown function. No metal binding or enzymatic activity can be detected for Memo, but Memo does bind directly to a specific ErbB2-derived phosphopeptide encompassing Tyr-1227 using its vestigial enzymatic active site. Memo thus represents a new class of phosphotyrosine-binding protein.

About this Structure

3BD0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Memo Is Homologous to Nonheme Iron Dioxygenases and Binds an ErbB2-derived Phosphopeptide in Its Vestigial Active Site., Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ, J Biol Chem. 2008 Feb 1;283(5):2734-40. Epub 2007 Nov 28. PMID:18045866 Page seeded by OCA on Sun May 4 20:39:02 2008

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