3bd9

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[[Image:3bd9.jpg|left|200px]]
[[Image:3bd9.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3bd9 |SIZE=350|CAPTION= <scene name='initialview01'>3bd9</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_3bd9", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:A3p+Binding+Site+For+Residue+A+347'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3&#39;-5&#39;-DIPHOSPHATE'>A3P</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/[Heparan_sulfate]-glucosamine_3-sulfotransferase_1 [Heparan sulfate]-glucosamine 3-sulfotransferase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.2.23 2.8.2.23] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HS3ST5, 3OST5, HS3OST5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_3bd9| PDB=3bd9 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bd9 OCA], [http://www.ebi.ac.uk/pdbsum/3bd9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bd9 RCSB]</span>
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}}
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'''human 3-O-sulfotransferase isoform 5 with bound PAP'''
'''human 3-O-sulfotransferase isoform 5 with bound PAP'''
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: [Heparan sulfate]-glucosamine 3-sulfotransferase 1]]
 
[[Category: Liu, J.]]
[[Category: Liu, J.]]
[[Category: Moon, A F.]]
[[Category: Moon, A F.]]
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[[Category: Xu, D.]]
[[Category: Xu, D.]]
[[Category: 3-o-sulfotransferase]]
[[Category: 3-o-sulfotransferase]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: golgi apparatus]]
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[[Category: Golgi apparatus]]
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[[Category: heparan sulfate]]
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[[Category: Heparan sulfate]]
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[[Category: heparan sulfate biosynthesis]]
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[[Category: Heparan sulfate biosynthesis]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: signal-anchor]]
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[[Category: Signal-anchor]]
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[[Category: substrate specificity]]
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[[Category: Substrate specificity]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:39:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:25:19 2008''
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Revision as of 17:39, 4 May 2008

Image:3bd9.jpg

Template:STRUCTURE 3bd9

human 3-O-sulfotransferase isoform 5 with bound PAP


Overview

The biosynthesis of heparan sulfate (HS) involves an array of specialized sulfotransferases. Here, we present a study aimed at engineering the substrate specificity of different HS 3-O-sulfotransferase isoforms. Based on the crystal structures, we identified a pair of amino acid residues responsible for selecting the substrates. Mutations of these residues altered the substrate specificities. Our results demonstrate the feasibility of tailoring the specificity of sulfotransferases to modify HS with desired functions.

About this Structure

3BD9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Engineering sulfotransferases to modify heparan sulfate., Xu D, Moon AF, Song D, Pedersen LC, Liu J, Nat Chem Biol. 2008 Mar;4(3):200-2. Epub 2008 Jan 27. PMID:18223645 Page seeded by OCA on Sun May 4 20:39:23 2008

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OCA

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