3be8

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[[Image:3be8.jpg|left|200px]]
[[Image:3be8.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3be8 |SIZE=350|CAPTION= <scene name='initialview01'>3be8</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_3be8", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= NLGN4X ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_3be8| PDB=3be8 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3be8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3be8 OCA], [http://www.ebi.ac.uk/pdbsum/3be8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3be8 RCSB]</span>
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}}
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'''Crystal structure of the synaptic protein neuroligin 4'''
'''Crystal structure of the synaptic protein neuroligin 4'''
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[[Category: Sulzenbacher, G.]]
[[Category: Sulzenbacher, G.]]
[[Category: Taylor, P.]]
[[Category: Taylor, P.]]
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[[Category: a/b-hydrolase fold]]
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[[Category: A/b-hydrolase fold]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: cell adhesion protein]]
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[[Category: Cell adhesion protein]]
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[[Category: four-helix bundle]]
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[[Category: Four-helix bundle]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: neuroligin]]
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[[Category: Neuroligin]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: synaptic protein]]
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[[Category: Synaptic protein]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:40:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:25:28 2008''
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Revision as of 17:40, 4 May 2008

Image:3be8.jpg

Template:STRUCTURE 3be8

Crystal structure of the synaptic protein neuroligin 4


Overview

The neuroligins are postsynaptic cell adhesion proteins whose associations with presynaptic neurexins participate in synaptogenesis. Mutations in the neuroligin and neurexin genes appear to be associated with autism and mental retardation. The crystal structure of a neuroligin reveals features not found in its catalytically active relatives, such as the fully hydrophobic interface forming the functional neuroligin dimer; the conformations of surface loops surrounding the vestigial active center; the location of determinants that are critical for folding and processing; and the absence of a macromolecular dipole and presence of an electronegative, hydrophilic surface for neurexin binding. The structure of a beta-neurexin-neuroligin complex reveals the precise orientation of the bound neurexin and, despite a limited resolution, provides substantial information on the Ca2+-dependent interactions network involved in trans-synaptic neurexin-neuroligin association. These structures exemplify how an alpha/beta-hydrolase fold varies in surface topography to confer adhesion properties and provide templates for analyzing abnormal processing or recognition events associated with autism.

About this Structure

3BE8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion., Fabrichny IP, Leone P, Sulzenbacher G, Comoletti D, Miller MT, Taylor P, Bourne Y, Marchot P, Neuron. 2007 Dec 20;56(6):979-91. PMID:18093521 Page seeded by OCA on Sun May 4 20:40:33 2008

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