3bes

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[[Image:3bes.jpg|left|200px]]
[[Image:3bes.jpg|left|200px]]
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{{Structure
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|PDB= 3bes |SIZE=350|CAPTION= <scene name='initialview01'>3bes</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_3bes", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+R+267'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+R+268'>AC2</scene>, <scene name='pdbsite=AC3:Bma+Binding+Site+For+Residue+R+269'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+R+270'>AC4</scene>, <scene name='pdbsite=AC5:Po4+Binding+Site+For+Residue+R+1'>AC5</scene>, <scene name='pdbsite=AC6:Po4+Binding+Site+For+Residue+L+139'>AC6</scene> and <scene name='pdbsite=AC7:Po4+Binding+Site+For+Residue+R+3'>AC7</scene>
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= IFNG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), C4R, IFNGR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12643 Ectromelia virus])
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|DOMAIN=
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{{STRUCTURE_3bes| PDB=3bes | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bes OCA], [http://www.ebi.ac.uk/pdbsum/3bes PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bes RCSB]</span>
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'''Structure of a Poxvirus ifngbp/ifng Complex'''
'''Structure of a Poxvirus ifngbp/ifng Complex'''
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[[Category: Nuara, A A]]
[[Category: Nuara, A A]]
[[Category: Walter, M R.]]
[[Category: Walter, M R.]]
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[[Category: antiviral defense]]
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[[Category: Antiviral defense]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: ectromelia virus]]
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[[Category: Ectromelia virus]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: immune system]]
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[[Category: Immune system]]
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[[Category: interferon]]
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[[Category: Interferon]]
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[[Category: orthopoxvirus]]
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[[Category: Orthopoxvirus]]
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[[Category: protein complex]]
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[[Category: Protein complex]]
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[[Category: receptor]]
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[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:41:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:25:37 2008''
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Revision as of 17:41, 4 May 2008

Image:3bes.jpg

Template:STRUCTURE 3bes

Structure of a Poxvirus ifngbp/ifng Complex


Contents

Overview

Ectromelia virus (ECTV) encodes an IFN-gamma-binding protein (IFN-gammaBP(ECTV)) that disrupts IFN-gamma signaling and its ability to induce an antiviral state within cells. IFN-gammaBP(ECTV) is an important virulence factor that is highly conserved (>90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox. The 2.2-A crystal structure of the IFN-gammaBP(ECTV)/IFN-gamma complex reveals IFN-gammaBP(ECTV) consists of an IFN-gammaR1 ligand-binding domain and a 57-aa helix-turn-helix (HTH) motif that is structurally related to the transcription factor TFIIA. The HTH motif forms a tetramerization domain that results in an IFN-gammaBP(ECTV)/IFN-gamma complex containing four IFN-gammaBP(ECTV) chains and two IFN-gamma dimers. The structure, combined with biochemical and cell-based assays, demonstrates that IFN-gammaBP(ECTV) tetramers are required for efficient IFN-gamma antagonism.

Disease

Known disease associated with this structure: AIDS, rapid progression to OMIM:[147570], Aplastic anemia OMIM:[147570], Interferon, immune, deficiency OMIM:[147570], Hepatitis C virus, resistance to OMIM:[147570], TSC2 angiomyolipomas, renal, modifier of OMIM:[147570], Tuberculosis, susceptibility to OMIM:[147570]

About this Structure

3BES is a Protein complex structure of sequences from Ectromelia virus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein., Nuara AA, Walter LJ, Logsdon NJ, Yoon SI, Jones BC, Schriewer JM, Buller RM, Walter MR, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1861-6. Epub 2008 Feb 5. PMID:18252829 Page seeded by OCA on Sun May 4 20:41:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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