3bev

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[[Image:3bev.jpg|left|200px]]
[[Image:3bev.jpg|left|200px]]
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{{Structure
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|PDB= 3bev |SIZE=350|CAPTION= <scene name='initialview01'>3bev</scene>, resolution 2.100&Aring;
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The line below this paragraph, containing "STRUCTURE_3bev", creates the "Structure Box" on the page.
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|GENE= BFIV21, B-FIV, BF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])
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{{STRUCTURE_3bev| PDB=3bev | SCENE= }}
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|RELATEDENTRY=[[3bew|3BEW]], [[1ogt|1OGT]], [[1oga|1OGA]], [[1sys|1SYS]], [[1a1m|1A1M]], [[1im9|1IM9]], [[1qqd|1QQD]], [[1kpr|1KPR]], [[1ktl|1KTL]], [[1mhe|1MHE]], [[2esv|2ESV]], [[1ydp|1YDP]], [[2dyp|2DYP]], [[2d31|2D31]], [[1kjv|1KJV]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bev FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bev OCA], [http://www.ebi.ac.uk/pdbsum/3bev PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bev RCSB]</span>
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'''11mer Structure of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding'''
'''11mer Structure of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding'''
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[[Category: Koch, M.]]
[[Category: Koch, M.]]
[[Category: 11mer]]
[[Category: 11mer]]
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[[Category: b21]]
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[[Category: B21]]
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[[Category: bf21]]
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[[Category: Bf21]]
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[[Category: bulge]]
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[[Category: Bulge]]
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[[Category: chicken]]
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[[Category: Chicken]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: immune response]]
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[[Category: Immune response]]
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[[Category: immune system]]
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[[Category: Immune system]]
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[[Category: immunoglobulin domain]]
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[[Category: Immunoglobulin domain]]
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[[Category: iron]]
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[[Category: metal-binding]]
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[[Category: Metal-binding]]
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[[Category: mhc class i]]
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[[Category: Mhc class i]]
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[[Category: mhc i]]
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[[Category: Mhc i]]
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[[Category: oxygen transport]]
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[[Category: Oxygen transport]]
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[[Category: peptide]]
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[[Category: Peptide]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: secreted]]
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[[Category: Secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:41:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:25:40 2008''
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Revision as of 17:41, 4 May 2008

Image:3bev.jpg

Template:STRUCTURE 3bev

11mer Structure of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding


Overview

Little is known about the structure of major histocompatibility complex (MHC) molecules outside of mammals. Only one class I molecule in the chicken MHC is highly expressed, leading to strong genetic associations with infectious pathogens. Here, we report two structures of the MHC class I molecule BF2( *)2101 from the B21 haplotype, which is known to confer resistance to Marek's disease caused by an oncogenic herpesvirus. The binding groove has an unusually large central cavity, which confers substantial conformational flexibility to the crucial residue Arg9, allowing remodeling of key peptide-binding sites. The coupled variation of anchor residues from the peptide, utilizing a charge-transfer system unprecedented in MHC molecules, allows peptides with conspicuously different sequences to be bound. This promiscuous binding extends our understanding of ways in which MHC class I molecules can present peptides to the immune system and might explain the resistance of the B21 haplotype to Marek's disease.

About this Structure

3BEV is a Protein complex structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding., Koch M, Camp S, Collen T, Avila D, Salomonsen J, Wallny HJ, van Hateren A, Hunt L, Jacob JP, Johnston F, Marston DA, Shaw I, Dunbar PR, Cerundolo V, Jones EY, Kaufman J, Immunity. 2007 Dec;27(6):885-99. PMID:18083574 Page seeded by OCA on Sun May 4 20:41:49 2008

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