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3bff

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[[Image:3bff.jpg|left|200px]]
[[Image:3bff.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3bff |SIZE=350|CAPTION= <scene name='initialview01'>3bff</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_3bff", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FPM:(5R,6S)-6-(1-HYDROXYETHYL)-7-OXO-3-[(2R)-OXOLAN-2-YL]-4-THIA-1-AZABICYCLO[3.2.0]HEPT-2-ENE-2-CARBOXYLIC+ACID'>FPM</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SFR:(2R)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-5-[(2R)-TETRAHYDROFURAN-2-YL]-2,3-DIHYDRO-1,3-THIAZOLE-4-CARBOXYLIC+ACID'>SFR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= bla-SED-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=67826 Citrobacter sedlakii])
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-->
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|DOMAIN=
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{{STRUCTURE_3bff| PDB=3bff | SCENE= }}
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|RELATEDENTRY=[[3bfc|3BFC]], [[3bfd|3BFD]], [[3bfe|3BFE]], [[3bfg|3BFG]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bff OCA], [http://www.ebi.ac.uk/pdbsum/3bff PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bff RCSB]</span>
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}}
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'''class A beta-lactamase SED-G238C complexed with faropenem'''
'''class A beta-lactamase SED-G238C complexed with faropenem'''
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[[Category: Petrella, S.]]
[[Category: Petrella, S.]]
[[Category: Sougakoff, W.]]
[[Category: Sougakoff, W.]]
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[[Category: acyl-enzyme]]
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[[Category: Acyl-enzyme]]
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[[Category: beta-lactamase]]
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[[Category: Beta-lactamase]]
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[[Category: class a sed-g238c]]
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[[Category: Class a sed-g238c]]
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[[Category: faropenem]]
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[[Category: Faropenem]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:43:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:25:46 2008''
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Revision as of 17:43, 4 May 2008

Image:3bff.jpg

Template:STRUCTURE 3bff

class A beta-lactamase SED-G238C complexed with faropenem


Overview

SED-1, a class A beta-lactamase from Citrobacter sedlakii, is a CTX-M-type extended-spectrum beta-lactamase that has the ability to hydrolyze expanded-spectrum cephalosporins such as cefotaxime. SED-1 and a SED mutant in which Gly238 has been replaced by a cysteine, forming a disulfide bridge with the other Cys residue located at position 69 (SED-G238C), have been crystallized. The crystals belong to the monoclinic space group C2, with unit-cell parameters a = 188.09, b = 73.65, c = 105.41 A, beta = 121.67 degrees for SED-1 and a = 187.64, b = 73.2, c = 103.89 A, beta = 121.89 degrees for the SED-G238C mutant. X-ray diffraction data were collected to maximum resolutions of 2.4 A for SED-1 and 2.0 A for SED-G238C.

About this Structure

3BFF is a Single protein structure of sequence from Citrobacter sedlakii. Full crystallographic information is available from OCA.

Reference

Crystallization and preliminary X-ray diffraction study of the class A beta-lactamase SED-1 and its mutant SED-G238C from Citrobacter sedlakii., Petrella S, Pernot L, Sougakoff W, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):125-8. Epub 2003, Dec 18. PMID:14684905 Page seeded by OCA on Sun May 4 20:43:00 2008

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