3bfg

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[[Image:3bfg.jpg|left|200px]]
[[Image:3bfg.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3bfg |SIZE=350|CAPTION= <scene name='initialview01'>3bfg</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_3bfg", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MER:(1R,5S,6S)-2-[(3S,5S)-5-DIMETHYLAMINOCARBONYLPYRROLIDIN-3-YLTHIO]-6-[(R)-1-HYDROXYETHYL]-1-METHYLCARBAPEN-2-EM-3-CARBOXYLIC+ACID'>MER</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= bla-SED-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=67826 Citrobacter sedlakii])
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-->
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|DOMAIN=
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{{STRUCTURE_3bfg| PDB=3bfg | SCENE= }}
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|RELATEDENTRY=[[3bfc|3BFC]], [[3bfd|3BFD]], [[3bfe|3BFE]], [[3bff|3BFF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bfg OCA], [http://www.ebi.ac.uk/pdbsum/3bfg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bfg RCSB]</span>
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}}
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'''class A beta-lactamase SED-G238C complexed with meropenem'''
'''class A beta-lactamase SED-G238C complexed with meropenem'''
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[[Category: Petrella, S.]]
[[Category: Petrella, S.]]
[[Category: Sougakoff, W.]]
[[Category: Sougakoff, W.]]
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[[Category: acyl-enzyme]]
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[[Category: Acyl-enzyme]]
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[[Category: beta-lactamase]]
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[[Category: Beta-lactamase]]
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[[Category: class some]]
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[[Category: Class some]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: meropenem]]
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[[Category: Meropenem]]
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[[Category: sed-g238c]]
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[[Category: Sed-g238c]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:43:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:25:50 2008''
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Revision as of 17:43, 4 May 2008

Image:3bfg.jpg

Template:STRUCTURE 3bfg

class A beta-lactamase SED-G238C complexed with meropenem


Overview

SED-1, a class A beta-lactamase from Citrobacter sedlakii, is a CTX-M-type extended-spectrum beta-lactamase that has the ability to hydrolyze expanded-spectrum cephalosporins such as cefotaxime. SED-1 and a SED mutant in which Gly238 has been replaced by a cysteine, forming a disulfide bridge with the other Cys residue located at position 69 (SED-G238C), have been crystallized. The crystals belong to the monoclinic space group C2, with unit-cell parameters a = 188.09, b = 73.65, c = 105.41 A, beta = 121.67 degrees for SED-1 and a = 187.64, b = 73.2, c = 103.89 A, beta = 121.89 degrees for the SED-G238C mutant. X-ray diffraction data were collected to maximum resolutions of 2.4 A for SED-1 and 2.0 A for SED-G238C.

About this Structure

3BFG is a Single protein structure of sequence from Citrobacter sedlakii. Full crystallographic information is available from OCA.

Reference

Crystallization and preliminary X-ray diffraction study of the class A beta-lactamase SED-1 and its mutant SED-G238C from Citrobacter sedlakii., Petrella S, Pernot L, Sougakoff W, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):125-8. Epub 2003, Dec 18. PMID:14684905 Page seeded by OCA on Sun May 4 20:43:04 2008

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