3bgs

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[[Image:3bgs.jpg|left|200px]]
[[Image:3bgs.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3bgs |SIZE=350|CAPTION= <scene name='initialview01'>3bgs</scene>, resolution 2.099&Aring;
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The line below this paragraph, containing "STRUCTURE_3bgs", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Residue+A+302'>AC1</scene>, <scene name='pdbsite=AC2:Po4+Binding+Site+For+Residue+A+303'>AC2</scene>, <scene name='pdbsite=AC3:Po4+Binding+Site+For+Residue+A+304'>AC3</scene> and <scene name='pdbsite=AC4:Dih+Binding+Site+For+Residue+A+301'>AC4</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DIH:3-HYDROXY-4-HYDROXYMETHYL-1-(4-OXO-4,4A,5,7A-TETRAHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YLMETHYL)-PYRROLIDINIUM'>DIH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= NP, PNP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_3bgs| PDB=3bgs | SCENE= }}
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|RELATEDENTRY=[[1rr6|1RR6]], [[1rt9|1RT9]], [[1rsz|1RSZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgs OCA], [http://www.ebi.ac.uk/pdbsum/3bgs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bgs RCSB]</span>
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}}
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'''Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate'''
'''Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate'''
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[[Category: Ramagopal, U A.]]
[[Category: Ramagopal, U A.]]
[[Category: Schramm, V L.]]
[[Category: Schramm, V L.]]
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[[Category: l-enantiomer]]
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[[Category: L-enantiomer]]
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[[Category: pnp]]
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[[Category: Pnp]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: transition state analogue]]
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[[Category: Transition state analogue]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:44:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:26:07 2008''
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Revision as of 17:44, 4 May 2008

Image:3bgs.jpg

Template:STRUCTURE 3bgs

Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate


Overview

Human purine nucleoside phosphorylase (PNP) was crystallized with transition-state analogue inhibitors Immucillin-H and DADMe-Immucillin-H synthesized with ribosyl mimics of l-stereochemistry. The inhibitors demonstrate that major driving forces for tight binding of these analogues are the leaving group interaction and the cationic mimicry of the transition state, even though large geometric changes occur with d-Immucillins and l-Immucillins bound to human PNP.

About this Structure

3BGS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase., Rinaldo-Matthis A, Murkin AS, Ramagopal UA, Clinch K, Mee SP, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL, J Am Chem Soc. 2008 Jan 23;130(3):842-4. Epub 2007 Dec 23. PMID:18154341 Page seeded by OCA on Sun May 4 20:44:52 2008

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