3biw

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[[Image:3biw.jpg|left|200px]]
[[Image:3biw.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3biw |SIZE=350|CAPTION= <scene name='initialview01'>3biw</scene>, resolution 3.500&Aring;
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The line below this paragraph, containing "STRUCTURE_3biw", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|ACTIVITY=
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|GENE= Nlgn1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), Nrxn1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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|DOMAIN=
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{{STRUCTURE_3biw| PDB=3biw | SCENE= }}
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|RELATEDENTRY=[[3bix|3BIX]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3biw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3biw OCA], [http://www.ebi.ac.uk/pdbsum/3biw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3biw RCSB]</span>
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}}
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'''Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex'''
'''Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex'''
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[[Category: Strop, P.]]
[[Category: Strop, P.]]
[[Category: Sudhof, T C.]]
[[Category: Sudhof, T C.]]
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[[Category: alpha-beta hydrolase]]
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[[Category: Alpha-beta hydrolase]]
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[[Category: alternative promoter usage]]
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[[Category: Alternative promoter usage]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: cell adhesion]]
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[[Category: Cell adhesion]]
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[[Category: cell adhesion/cell adhesion complex]]
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[[Category: Cell adhesion/cell adhesion complex]]
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[[Category: cell junction]]
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[[Category: Cell junction]]
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[[Category: esterase domain]]
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[[Category: Esterase domain]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: lns domain]]
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[[Category: Lns domain]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: postsynaptic cell membrane]]
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[[Category: Postsynaptic cell membrane]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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[[Category: synapse]]
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[[Category: Synapse]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:49:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:26:45 2008''
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Revision as of 17:49, 4 May 2008

Template:STRUCTURE 3biw

Crystal structure of the Neuroligin-1/Neurexin-1beta synaptic adhesion complex


Overview

Neurexins and neuroligins provide trans-synaptic connectivity by the Ca2+-dependent interaction of their alternatively spliced extracellular domains. Neuroligins specify synapses in an activity-dependent manner, presumably by binding to neurexins. Here, we present the crystal structures of neuroligin-1 in isolation and in complex with neurexin-1 beta. Neuroligin-1 forms a constitutive dimer, and two neurexin-1 beta monomers bind to two identical surfaces on the opposite faces of the neuroligin-1 dimer to form a heterotetramer. The neuroligin-1/neurexin-1 beta complex exhibits a nanomolar affinity and includes a large binding interface that contains bound Ca2+. Alternatively spliced sites in neurexin-1 beta and in neuroligin-1 are positioned nearby the binding interface, explaining how they regulate the interaction. Structure-based mutations of neuroligin-1 at the interface disrupt binding to neurexin-1 beta, but not the folding of neuroligin-1 and confirm the validity of the binding interface of the neuroligin-1/neurexin-1 beta complex. Our results provide molecular insights for understanding the role of cell-adhesion proteins in synapse function.

About this Structure

3BIW is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions., Arac D, Boucard AA, Ozkan E, Strop P, Newell E, Sudhof TC, Brunger AT, Neuron. 2007 Dec 20;56(6):992-1003. PMID:18093522 Page seeded by OCA on Sun May 4 20:49:55 2008

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