1aoj
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(New page: 200px<br /><applet load="1aoj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aoj, resolution 2.5Å" /> '''THE SH3 DOMAIN OF EPS...)
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Revision as of 08:52, 20 November 2007
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THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER
Overview
SH3 domains are structurally well-characterized as monomeric modular units, of protein structure that mediate protein-protein recognition in numerous, signal transduction proteins. The X-ray crystallographic structure of the, Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the, SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in, vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.
About this Structure
1AOJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The SH3 domain of Eps8 exists as a novel intertwined dimer., Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME, Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:9303002
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