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2bz6

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(New page: 200px<br /> <applet load="2bz6" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bz6, resolution 1.60&Aring;" /> '''ORALLY AVAILABLE FA...)
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Revision as of 17:16, 29 October 2007

Image:2bz6.gif

2bz6, resolution 1.60Å

Drag the structure with the mouse to rotate

ORALLY AVAILABLE FACTOR7A INHIBITOR

Overview

The discovery of a highly potent and selective tissue factor/factor VIIa, inhibitor is described. Upon oral administration of its double prodrug in, the guinea pig, a dose-dependent antithrombotic effect is observed in an, established model of arterial thrombosis without prolonging bleeding time., The pharmacodynamic properties of this selective inhibitor are compared to, the behaviour of a mixed factor VIIa/factor Xa inhibitor.

About this Structure

2BZ6 is a [Single protein] structure of sequence from [Homo sapiens] with SO4, CA and 346 as [ligands]. Active as [[1]], with EC number [3.4.21.21]. Full crystallographic information is available from [OCA].

Reference

Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity., Groebke Zbinden K, Banner DW, Hilpert K, Himber J, Lave T, Riederer MA, Stahl M, Tschopp TB, Obst-Sander U, Bioorg Med Chem. 2006 Aug 1;14(15):5357-69. Epub 2006 Apr 18. PMID:16621574

Page seeded by OCA on Mon Oct 29 19:21:29 2007

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