3bq7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:3bq7.jpg|left|200px]]
[[Image:3bq7.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 3bq7 |SIZE=350|CAPTION= <scene name='initialview01'>3bq7</scene>, resolution 2.900&Aring;
+
The line below this paragraph, containing "STRUCTURE_3bq7", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Diacylglycerol_kinase Diacylglycerol kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.107 2.7.1.107] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= DGKD, KIAA0145 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00166 SAM]</span>
+
{{STRUCTURE_3bq7| PDB=3bq7 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bq7 OCA], [http://www.ebi.ac.uk/pdbsum/3bq7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bq7 RCSB]</span>
+
-
}}
+
'''SAM domain of Diacylglycerol Kinase delta1 (E35G)'''
'''SAM domain of Diacylglycerol Kinase delta1 (E35G)'''
Line 29: Line 26:
[[Category: Knight, M J.]]
[[Category: Knight, M J.]]
[[Category: Sawaya, M R.]]
[[Category: Sawaya, M R.]]
-
[[Category: alternative splicing]]
+
[[Category: Alternative splicing]]
-
[[Category: cytoplasm]]
+
[[Category: Cytoplasm]]
-
[[Category: kinase]]
+
[[Category: Kinase]]
-
[[Category: membrane]]
+
[[Category: Membrane]]
-
[[Category: metal-binding]]
+
[[Category: Metal-binding]]
-
[[Category: phorbol-ester binding]]
+
[[Category: Phorbol-ester binding]]
-
[[Category: phosphoprotein]]
+
[[Category: Phosphoprotein]]
-
[[Category: polymerization domain]]
+
[[Category: Polymerization domain]]
-
[[Category: sam domain]]
+
[[Category: Sam domain]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
[[Category: zinc]]
+
[[Category: Zinc]]
-
[[Category: zinc-finger]]
+
[[Category: Zinc-finger]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:00:12 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:28:13 2008''
+

Revision as of 18:00, 4 May 2008

Image:3bq7.jpg

Template:STRUCTURE 3bq7

SAM domain of Diacylglycerol Kinase delta1 (E35G)


Overview

The diacylglycerol kinase (DGK) enzymes function as regulators of intracellular signaling by altering the levels of the second messengers, diacylglycerol and phosphatidic acid. The DGK delta and eta isozymes possess a common protein-protein interaction module known as a sterile alpha-motif (SAM) domain. In DGK delta, SAM domain self-association inhibits the translocation of DGK delta to the plasma membrane. Here we show that DGK delta SAM forms a polymer and map the polymeric interface by a genetic selection for soluble mutants. A crystal structure reveals that DGKSAM forms helical polymers through a head-to-tail interaction similar to other SAM domain polymers. Disrupting polymerization by polymer interface mutations constitutively localizes DGK delta to the plasma membrane. Thus, polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location. Regulation by dynamic polymerization is an emerging theme in signal transduction.

About this Structure

3BQ7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Regulation of Enzyme Localization by Polymerization: Polymer Formation by the SAM Domain of Diacylglycerol Kinase delta1., Harada BT, Knight MJ, Imai S, Qiao F, Ramachander R, Sawaya MR, Gingery M, Sakane F, Bowie JU, Structure. 2008 Mar;16(3):380-7. PMID:18334213 Page seeded by OCA on Sun May 4 21:00:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bq7"
Personal tools