3bz8

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[[Image:3bz8.jpg|left|200px]]
[[Image:3bz8.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3bz8 |SIZE=350|CAPTION= <scene name='initialview01'>3bz8</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_3bz8", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+997'>AC1</scene>, <scene name='pdbsite=AC2:Vo4+Binding+Site+For+Residue+A+998'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Residue+A+999'>AC3</scene>, <scene name='pdbsite=AC4:Adp+Binding+Site+For+Residue+A+1000'>AC4</scene>, <scene name='pdbsite=AC5:Edo+Binding+Site+For+Residue+A+1001'>AC5</scene> and <scene name='pdbsite=AC6:Bl6+Binding+Site+For+Residue+A+800'>AC6</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BL6:(3AS)-3A-HYDROXY-7-METHYL-1-PHENYL-1,2,3,3A-TETRAHYDRO-4H-PYRROLO[2,3-B]QUINOLIN-4-ONE'>BL6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= mhcA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 Dictyostelium discoideum])
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-->
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|DOMAIN=
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{{STRUCTURE_3bz8| PDB=3bz8 | SCENE= }}
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|RELATEDENTRY=[[1yv3|1YV3]], [[3bz7|3BZ7]], [[3bz9|3BZ9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bz8 OCA], [http://www.ebi.ac.uk/pdbsum/3bz8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3bz8 RCSB]</span>
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}}
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'''Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II'''
'''Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II'''
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[[Category: Allingham, J S.]]
[[Category: Allingham, J S.]]
[[Category: Rayment, I.]]
[[Category: Rayment, I.]]
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[[Category: actin-binding]]
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[[Category: Actin-binding]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: blebbistatin analogue]]
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[[Category: Blebbistatin analogue]]
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[[Category: calmodulin-binding]]
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[[Category: Calmodulin-binding]]
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[[Category: coiled coil]]
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[[Category: Coiled coil]]
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[[Category: contractile protein]]
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[[Category: Contractile protein]]
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[[Category: cytoplasm]]
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[[Category: Cytoplasm]]
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[[Category: methylation]]
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[[Category: Methylation]]
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[[Category: motor domain]]
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[[Category: Motor domain]]
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[[Category: motor protein]]
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[[Category: Motor protein]]
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[[Category: myosin inhibitor]]
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[[Category: Myosin inhibitor]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphoprotein]]
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[[Category: Phosphoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:13:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:29:48 2008''
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Revision as of 18:13, 4 May 2008

Image:3bz8.jpg

Template:STRUCTURE 3bz8

Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II


Overview

Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.

About this Structure

3BZ8 is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

The structural basis of blebbistatin inhibition and specificity for myosin II., Allingham JS, Smith R, Rayment I, Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6. PMID:15750603 Page seeded by OCA on Sun May 4 21:13:29 2008

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