3c9r

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[[Image:3c9r.jpg|left|200px]]
[[Image:3c9r.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 3c9r |SIZE=350|CAPTION= <scene name='initialview01'>3c9r</scene>, resolution 2.300&Aring;
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The line below this paragraph, containing "STRUCTURE_3c9r", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+309'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+A+310'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Residue+A+311'>AC3</scene>, <scene name='pdbsite=AC4:Mg+Binding+Site+For+Residue+A+312'>AC4</scene>, <scene name='pdbsite=AC5:Mg+Binding+Site+For+Residue+B+309'>AC5</scene>, <scene name='pdbsite=AC6:Mg+Binding+Site+For+Residue+B+310'>AC6</scene>, <scene name='pdbsite=AC7:Mg+Binding+Site+For+Residue+B+311'>AC7</scene>, <scene name='pdbsite=AC8:Mg+Binding+Site+For+Residue+B+312'>AC8</scene>, <scene name='pdbsite=AC9:Atp+Binding+Site+For+Residue+B+307'>AC9</scene> and <scene name='pdbsite=BC1:Atp+Binding+Site+For+Residue+A+307'>BC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-phosphate_kinase Thiamine-phosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.16 2.7.4.16] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= thiL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=63363 Aquifex aeolicus])
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-->
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02194 ThiL_N], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG0611 ThiL]</span>
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{{STRUCTURE_3c9r| PDB=3c9r | SCENE= }}
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|RELATEDENTRY=[[3c9s|3C9S]], [[3c9t|3C9T]], [[3c9u|3C9U]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c9r OCA], [http://www.ebi.ac.uk/pdbsum/3c9r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3c9r RCSB]</span>
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}}
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'''AaThiL complexed with ATP'''
'''AaThiL complexed with ATP'''
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[[Category: Kinsland, C.]]
[[Category: Kinsland, C.]]
[[Category: McCulloch, K M.]]
[[Category: McCulloch, K M.]]
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[[Category: alpha-beta structure]]
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[[Category: Alpha-beta structure]]
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[[Category: beta barrel]]
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[[Category: Beta barrel]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:30:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:31:18 2008''
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Revision as of 18:30, 4 May 2008

Image:3c9r.jpg

Template:STRUCTURE 3c9r

AaThiL complexed with ATP


Overview

Thiamin monophosphate kinase (ThiL) catalyzes the ATP-dependent phosphorylation of thiamin monophosphate (TMP) to form thiamin pyrophosphate (TPP), the active form of vitamin B 1. ThiL is a member of a small ATP binding superfamily that also includes the purine biosynthetic enzymes, PurM and PurL, NiFe hydrogenase maturation protein, HypE, and selenophosphate synthase, SelD. The latter four enzymes are believed to utilize phosphorylated intermediates during catalysis. To understand the mechanism of ThiL and its relationship to the other superfamily members, we determined the structure of Aquifex aeolicus ThiL (AaThiL) with nonhydrolyzable AMP-PCP and TMP, and also with the products of the reaction, ADP and TPP. The results suggest that AaThiL utilizes a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. The structure of ThiL is compared to those of PurM, PurL, and HypE, and the ATP binding site is compared to that of PurL, for which nucleotide complexes are available.

About this Structure

3C9R is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Structural studies of thiamin monophosphate kinase in complex with substrates and products(,)., McCulloch KM, Kinsland C, Begley TP, Ealick SE, Biochemistry. 2008 Mar 25;47(12):3810-21. Epub 2008 Mar 1. PMID:18311927 Page seeded by OCA on Sun May 4 21:30:00 2008

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