3ctn

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[[Image:3ctn.gif|left|200px]]
[[Image:3ctn.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 3ctn |SIZE=350|CAPTION= <scene name='initialview01'>3ctn</scene>
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The line below this paragraph, containing "STRUCTURE_3ctn", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= CTNC(A-CYS) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])
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|DOMAIN=
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{{STRUCTURE_3ctn| PDB=3ctn | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ctn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ctn OCA], [http://www.ebi.ac.uk/pdbsum/3ctn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3ctn RCSB]</span>
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'''STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES'''
'''STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES'''
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[[Category: Spyracopoulos, L.]]
[[Category: Spyracopoulos, L.]]
[[Category: Sykes, B D.]]
[[Category: Sykes, B D.]]
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[[Category: calcium-binding protein]]
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[[Category: Calcium-binding protein]]
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[[Category: cardiac]]
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[[Category: Cardiac]]
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[[Category: muscle]]
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[[Category: Muscle]]
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[[Category: regulatory]]
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[[Category: Regulatory]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:59:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:32:50 2008''
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Revision as of 18:59, 4 May 2008

Image:3ctn.gif

Template:STRUCTURE 3ctn

STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES


Overview

The regulation of cardiac muscle contraction must differ from that of skeletal muscles to effect different physiological and contractile properties. Cardiac troponin C (TnC), the key regulator of cardiac muscle contraction, possesses different functional and Ca2+-binding properties compared with skeletal TnC and features a Ca2+-binding site I, which is naturally inactive. The structure of cardiac TnC in the Ca2+-saturated state has been determined by nuclear magnetic resonance spectroscopy. The regulatory domain exists in a "closed" conformation even in the Ca2+-bound (the "on") state, in contrast to all predicted models and differing significantly from the calcium-induced structure observed in skeletal TnC. This structure in the Ca2+-bound state, and its subsequent interaction with troponin I (TnI), are crucial in determining the specific regulatory mechanism for cardiac muscle contraction. Further, it will allow for an understanding of the action of calcium-sensitizing drugs, which bind to cardiac TnC and are known to enhance the ability of cardiac TnC to activate cardiac muscle contraction.

About this Structure

3CTN is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain., Sia SK, Li MX, Spyracopoulos L, Gagne SM, Liu W, Putkey JA, Sykes BD, J Biol Chem. 1997 Jul 18;272(29):18216-21. PMID:9218458 Page seeded by OCA on Sun May 4 21:59:14 2008

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