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3gcb

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[[Image:3gcb.gif|left|200px]]
[[Image:3gcb.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 3gcb |SIZE=350|CAPTION= <scene name='initialview01'>3gcb</scene>, resolution 1.87&Aring;
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The line below this paragraph, containing "STRUCTURE_3gcb", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=A73:Nucleophilic+CYS+Mutated+To+ALA'>A73</scene> and <scene name='pdbsite=NUL:Catalytic+Residues'>NUL</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= GAL6C73ADELK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_3gcb| PDB=3gcb | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gcb OCA], [http://www.ebi.ac.uk/pdbsum/3gcb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3gcb RCSB]</span>
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}}
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'''GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A/DELTAK454'''
'''GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A/DELTAK454'''
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[[Category: Joshua-Tor, L.]]
[[Category: Joshua-Tor, L.]]
[[Category: Zheng, W.]]
[[Category: Zheng, W.]]
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[[Category: bleomycin hydrolase]]
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[[Category: Bleomycin hydrolase]]
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[[Category: dna-binding protein]]
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[[Category: Dna-binding protein]]
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[[Category: peptidase]]
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[[Category: Peptidase]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: self-compartmentalizing protease]]
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[[Category: Self-compartmentalizing protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:02:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:33:30 2008''
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Revision as of 19:02, 4 May 2008

Image:3gcb.gif

Template:STRUCTURE 3gcb

GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A/DELTAK454


Overview

The Gal6 protease is in a class of cysteine peptidases identified by their ability to inactivate the anti-cancer drug bleomycin. The protein forms a barrel structure with the active sites embedded in a channel as in the proteasome. In Gal6 the C termini lie in the active site clefts. We show that Gal6 acts as a carboxypeptidase on its C terminus to convert itself to an aminopeptidase and peptide ligase. The substrate specificity of the peptidase activity is determined by the position of the C terminus of Gal6 rather than the sequence of the substrate. We propose a model to explain these diverse activities and Gal6's singular ability to inactivate bleomycin.

About this Structure

3GCB is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase., Zheng W, Johnston SA, Joshua-Tor L, Cell. 1998 Apr 3;93(1):103-9. PMID:9546396 Page seeded by OCA on Sun May 4 22:02:34 2008

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