3nse

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:3nse.jpg|left|200px]]
[[Image:3nse.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 3nse |SIZE=350|CAPTION= <scene name='initialview01'>3nse</scene>, resolution 2.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_3nse", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ITU:ETHYLISOTHIOUREA'>ITU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase Nitric-oxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_3nse| PDB=3nse | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nse OCA], [http://www.ebi.ac.uk/pdbsum/3nse PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3nse RCSB]</span>
+
-
}}
+
'''BOVINE ENOS, H4B-FREE, SEITU COMPLEX'''
'''BOVINE ENOS, H4B-FREE, SEITU COMPLEX'''
Line 32: Line 29:
[[Category: Poulos, T L.]]
[[Category: Poulos, T L.]]
[[Category: Raman, C S.]]
[[Category: Raman, C S.]]
-
[[Category: complex (oxidoreductase/peptide)]]
+
[[Category: Heme protein]]
-
[[Category: heme protein]]
+
[[Category: Nitric oxide synthase]]
-
[[Category: nitric oxide synthase]]
+
[[Category: Tetrahydrobiopterin]]
-
[[Category: tetrahydrobiopterin]]
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:08:17 2008''
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:34:54 2008''
+

Revision as of 19:08, 4 May 2008

Image:3nse.jpg

Template:STRUCTURE 3nse

BOVINE ENOS, H4B-FREE, SEITU COMPLEX


Overview

Nitric oxide, a key signaling molecule, is produced by a family of enzymes collectively called nitric oxide synthases (NOS). Here, we report the crystal structure of the heme domain of endothelial NOS in tetrahydrobiopterin (H4B)-free and -bound forms at 1.95 A and 1.9 A resolution, respectively. In both structures a zinc ion is tetrahedrally coordinated to pairs of symmetry-related cysteine residues at the dimer interface. The phylogenetically conserved Cys-(X)4-Cys motif and its strategic location establish a structural role for the metal center in maintaining the integrity of the H4B-binding site. The unexpected recognition of the substrate, L-arginine, at the H4B site indicates that this site is poised to stabilize a positively charged pterin ring and suggests a model involving a cationic pterin radical in the catalytic cycle.

About this Structure

3NSE is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center., Raman CS, Li H, Martasek P, Kral V, Masters BS, Poulos TL, Cell. 1998 Dec 23;95(7):939-50. PMID:9875848 Page seeded by OCA on Sun May 4 22:08:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3nse"
Personal tools