3sdp

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[[Image:3sdp.jpg|left|200px]]
[[Image:3sdp.jpg|left|200px]]
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{{Structure
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|PDB= 3sdp |SIZE=350|CAPTION= <scene name='initialview01'>3sdp</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_3sdp", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span>
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{{STRUCTURE_3sdp| PDB=3sdp | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdp OCA], [http://www.ebi.ac.uk/pdbsum/3sdp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3sdp RCSB]</span>
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'''THE 2.1 ANGSTROMS RESOLUTION STRUCTURE OF IRON SUPEROXIDE DISMUTASE FROM PSEUDOMONAS OVALIS'''
'''THE 2.1 ANGSTROMS RESOLUTION STRUCTURE OF IRON SUPEROXIDE DISMUTASE FROM PSEUDOMONAS OVALIS'''
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[[Category: Ringe, D.]]
[[Category: Ringe, D.]]
[[Category: Stoddard, B L.]]
[[Category: Stoddard, B L.]]
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[[Category: oxidoreductase (superoxide acceptor)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:12:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:36:03 2008''
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Revision as of 19:12, 4 May 2008

Image:3sdp.jpg

Template:STRUCTURE 3sdp

THE 2.1 ANGSTROMS RESOLUTION STRUCTURE OF IRON SUPEROXIDE DISMUTASE FROM PSEUDOMONAS OVALIS


Overview

The 2.1-A resolution crystal structure of native uncomplexed iron superoxide dismutase (EC 1.15.1.1) from Pseudomonas ovalis was solved and refined to a final R factor of 24%. The dimeric structure contains one catalytic iron center per monomer with an asymmetric trigonal-bipyramidal coordination of protein ligands to the metal. Each monomer contains two domains, with the trigonal ligands (histidines 74 and 160; aspartate 156) contributed by the large domain and stabilized by an extended hydrogen-bonded network, including residues from opposing monomers. The axial ligand (histidine 26) is found on the small domain and does not participate extensively in the stabilizing H-bond network. The open axial coordination position of the iron is devoid of bound water molecules or anions. The metal is located 0.5 A out of the plane of the trigonal ligands toward histidine 26, providing a slightly skewed coordination away from the iron binding site. The molecule contains a glutamine residue in the active site which is conserved between all iron enzymes sequenced to data but which is conserved among all manganese SODs at a separate position in the sequence. This residue shows the same structural interactions in both cases, implying that iron and manganese SODs are second-site revertants of one another.

About this Structure

3SDP is a Single protein structure of sequence from Pseudomonas putida. The following page contains interesting information on the relation of 3SDP with [Superoxide Dismutase]. Full crystallographic information is available from OCA.

Reference

The 2.1-A resolution structure of iron superoxide dismutase from Pseudomonas ovalis., Stoddard BL, Howell PL, Ringe D, Petsko GA, Biochemistry. 1990 Sep 25;29(38):8885-93. PMID:2271564 Page seeded by OCA on Sun May 4 22:12:54 2008

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