1avq
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(New page: 200px<br /><applet load="1avq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1avq, resolution 2.4Å" /> '''TOROIDAL STRUCTURE OF...)
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Revision as of 09:02, 20 November 2007
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TOROIDAL STRUCTURE OF LAMBDA EXONUCLEASE DETERMINED AT 2.4 ANGSTROMS
Overview
Structure determination at 2.4 angstrom resolution shows that, lambda-exonuclease consists of three subunits that form a toroid. The, central channel is funnel shaped, tapering from an inner diameter of about, 30 angstroms at the wider end to 15 angstroms at the narrow end. This is, adequate to accommodate the DNA substrate and thus provides a structural, basis for the ability of the enzyme to sequentially hydrolyze thousands of, nucleotides in a highly processive manner. The results also suggest the, locations of the active sites and the constraints that limit cleavage to a, single strand.
About this Structure
1AVQ is a Single protein structure of sequence from Enterobacteria phage lambda with PO4 and ACT as ligands. Active as Exodeoxyribonuclease (lambda-induced), with EC number 3.1.11.3 Full crystallographic information is available from OCA.
Reference
Toroidal structure of lambda-exonuclease., Kovall R, Matthews BW, Science. 1997 Sep 19;277(5333):1824-7. PMID:9295273
Page seeded by OCA on Tue Nov 20 11:09:47 2007
